Discovery of small molecule Gαq/11 protein inhibitors against uveal melanoma

by Compuscript LtdGraphical abstract:Constitutively activated Gαq/11 proteins drive the vast majority of uveal melanoma (UM). GQ262 effectively combats UM both in vitro and in vivo by targeting Gαq/11

Oncology December 21,2023

Discovery of small molecule Gαq/11 protein inhibitors against uveal melanoma

by Compuscript LtdGraphical abstract:Constitutively activated Gαq/11 proteins drive the vast majority of uveal melanoma (UM). GQ262 effectively combats UM both in vitro and in vivo by targeting Gαq/11

Oncology December 21,2023

Marker for therapy response in acute myeloid leukemia identified

byGerman Cancer Research CenterCell line sensitivity and additional patient data. A IC50s for VEN of 19 AML cell lines classified as primitive (Prim-AML, n = 11) or monocytic (Mono-AML, n = 8) t

Oncology December 21,2023

Marker for therapy response in acute myeloid leukemia identified

byGerman Cancer Research CenterCell line sensitivity and additional patient data. A IC50s for VEN of 19 AML cell lines classified as primitive (Prim-AML, n = 11) or monocytic (Mono-AML, n = 8) t

Oncology December 21,2023

Discovery explains cancer chemotherapy resistance, offers solution

byCornell UniversityGraphical abstract. Credit:Molecular Cell(2022). DOI: 10.1016/j.molcel.2022.08.028Researchers have uncovered a novel pathway that explains how cancer cells become

Oncology December 21,2023

Discovery explains cancer chemotherapy resistance, offers solution

byCornell UniversityGraphical abstract. Credit:Molecular Cell(2022). DOI: 10.1016/j.molcel.2022.08.028Researchers have uncovered a novel pathway that explains how cancer cells become

Oncology December 21,2023

Key mechanisms to improve intestinal regeneration and alleviate the side effects of radiotherapy discovered

byThe Spanish National Cancer Research CentreCredit: CC0 Public DomainThe intestine is very susceptible and is affected by the harsh conditions caused by DNA-altering agents, such as radiation a

Gastroenterology December 21,2023

Key mechanisms to improve intestinal regeneration and alleviate the side effects of radiotherapy discovered

byThe Spanish National Cancer Research CentreCredit: CC0 Public DomainThe intestine is very susceptible and is affected by the harsh conditions caused by DNA-altering agents, such as radiation a

Gastroenterology December 21,2023

Recruitment mechanism discovered for cancer-associated fibroblasts in common lung cancer

byUniversity of BarcelonaGenetic models to mimic SMAD2/3 alterations in patient-derived ADC-TAFs and SCC-TAFs. a–c, Fold SMAD3 (a) and SMAD2 (b) mRNA and corresponding ratio (c) in primary lung

Oncology December 21,2023

Recruitment mechanism discovered for cancer-associated fibroblasts in common lung cancer

byUniversity of BarcelonaGenetic models to mimic SMAD2/3 alterations in patient-derived ADC-TAFs and SCC-TAFs. a–c, Fold SMAD3 (a) and SMAD2 (b) mRNA and corresponding ratio (c) in primary lung

Oncology December 21,2023

Chinese medicine ingredients found to generate autophagic flux to suppress tumor progression in gastric cancer

byScience China PressActivation of Beclin-1 by piceatannol promotes autophagic flux in GC cells, and combined with everolimus, triggers autophagic death, ultimately inhibiting tumor progression,

Oncology December 21,2023

Chinese medicine ingredients found to generate autophagic flux to suppress tumor progression in gastric cancer

byScience China PressActivation of Beclin-1 by piceatannol promotes autophagic flux in GC cells, and combined with everolimus, triggers autophagic death, ultimately inhibiting tumor progression,

Oncology December 21,2023

HDAC6 score found to predict the response of some cancers to ricolinostat

by Bob Yirka , Medical XpressHDAC6 score in BC. (a) The number of samples and dataset of origin used to evaluate the HDAC6 regulon. (b) Overlap of the original and updated HDAC6 regulons. P value was

Oncology December 21,2023

HDAC6 score found to predict the response of some cancers to ricolinostat

by Bob Yirka , Medical XpressHDAC6 score in BC. (a) The number of samples and dataset of origin used to evaluate the HDAC6 regulon. (b) Overlap of the original and updated HDAC6 regulons. P value was

Oncology December 21,2023

Survival rates high for children, teens with melanoma

by Lori SolomonSurvival rates for children and adolescents with melanomas are high, according to a study published online Dec. 9 in theJournal of the American Academy of Dermatology.Mary-Ann El

Oncology December 21,2023

Survival rates high for children, teens with melanoma

by Lori SolomonSurvival rates for children and adolescents with melanomas are high, according to a study published online Dec. 9 in theJournal of the American Academy of Dermatology.Mary-Ann El

Oncology December 21,2023

Splicing deregulation detected and targeted in type of childhood leukemia

byUniversity of California - San DiegoA micrograph depicts acute myeloid leukemia cells. Though treatments have dramatically advanced, AML in children can become resistant to therapy. New resear

Oncology December 21,2023

Splicing deregulation detected and targeted in type of childhood leukemia

byUniversity of California - San DiegoA micrograph depicts acute myeloid leukemia cells. Though treatments have dramatically advanced, AML in children can become resistant to therapy. New resear

Oncology December 21,2023

Pharmacotyping of childhood leukemia provides a blueprint for 'true precision medicine'

bySt. Jude Children's Research HospitalWenjian Yang, Shawn Lee, MBBS, and Jun J. Yang, PhD, recently published a comprehensive study pharmacotyping childhood leukemia. Credit: St. Jude Child

Oncology December 21,2023

Pharmacotyping of childhood leukemia provides a blueprint for 'true precision medicine'

bySt. Jude Children's Research HospitalWenjian Yang, Shawn Lee, MBBS, and Jun J. Yang, PhD, recently published a comprehensive study pharmacotyping childhood leukemia. Credit: St. Jude Child

Oncology December 21,2023