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Pelage Pharmaceuticals Advances Hair Loss Treatment with Phase 2 Study and $14M Funding

Pelage Pharmaceuticals Advances Hair Loss Treatment with Phase 2 Study and $14M Funding

Pelage Pharmaceuticals has commenced dosing the first patients in its Phase 2a clinical trial for PP405, a novel topical treatment designed to reactivate dormant hair follicle stem cells.
Dermatology August 14,2024
Pelage Pharmaceuticals Advances Hair Loss Treatment with Phase 2 Study and $14M Funding

Pelage Pharmaceuticals Advances Hair Loss Treatment with Phase 2 Study and $14M Funding

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Blood Types: What Letters, Positive, and Negative Signs Mean

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Developing deep learning models to understand the human genome

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by Olivia Dimmer,Northwestern UniversityDeveloping deep learning models to identify polyA sites at nucleotide-level resolution and calculate polyA site strength. Credit:Nature Communicatio
Genetics February 19,2024
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by Olivia Dimmer,Northwestern UniversityDeveloping deep learning models to identify polyA sites at nucleotide-level resolution and calculate polyA site strength. Credit:Nature Communicatio
Genetics February 19,2024
New framework to identify genetic risk of disease could lead to targeted therapeutics

New framework to identify genetic risk of disease could lead to targeted therapeutics

by Brigham and Women’s HospitalChemical perturbations expand the phenotypic space of quantitative blood profiles, and blood cell responses are associated with clinical phenotypes and genetic vari
Genetics February 19,2024
New framework to identify genetic risk of disease could lead to targeted therapeutics

New framework to identify genetic risk of disease could lead to targeted therapeutics

by Brigham and Women’s HospitalChemical perturbations expand the phenotypic space of quantitative blood profiles, and blood cell responses are associated with clinical phenotypes and genetic vari
Genetics February 19,2024
Researchers discover first-ever link between hemoglobin-like protein and normal heart development

Researchers discover first-ever link between hemoglobin-like protein and normal heart development

by University of Maryland School of Medicinecygb2mutant phenotype presents organ laterality defects.aCRISPR/Cas9 mediated genome editing ofcygb2. Two different gRNA were t
Genetics February 19,2024
Researchers discover first-ever link between hemoglobin-like protein and normal heart development

Researchers discover first-ever link between hemoglobin-like protein and normal heart development

by University of Maryland School of Medicinecygb2mutant phenotype presents organ laterality defects.aCRISPR/Cas9 mediated genome editing ofcygb2. Two different gRNA were t
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New insights into intervertebral disk degeneration: Role of oxygen concentration and HIF1A in nucleus pulposus cells

New insights into intervertebral disk degeneration: Role of oxygen concentration and HIF1A in nucleus pulposus cells

by Chongqing Medical UniversityTranscriptomic analysis and validation of NPCs. Credit:Genes & DiseasesIn arapid communicationpublished in the journalGenes & Diseases, r
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New insights into intervertebral disk degeneration: Role of oxygen concentration and HIF1A in nucleus pulposus cells

New insights into intervertebral disk degeneration: Role of oxygen concentration and HIF1A in nucleus pulposus cells

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Chronic migraine research finds genetic mechanism to lower migraine frequency

Chronic migraine research finds genetic mechanism to lower migraine frequency

by Niki Widdowson,Queensland University of TechnologyManhattan plot from the epigenome‐wide association study of baseline DNA methylation predicting treatment response. Manhattan plot showing th
Genetics February 19,2024
Chronic migraine research finds genetic mechanism to lower migraine frequency

Chronic migraine research finds genetic mechanism to lower migraine frequency

by Niki Widdowson,Queensland University of TechnologyManhattan plot from the epigenome‐wide association study of baseline DNA methylation predicting treatment response. Manhattan plot showing th
Genetics February 19,2024
Newly discovered genetic mutation protects against Parkinson's disease and offers hope for new therapies

Newly discovered genetic mutation protects against Parkinson's disease and offers hope for new therapies

by University of Southern CaliforniaCredit: Unsplash/CC0 Public DomainA previously unidentified genetic mutation in a small protein provides significant protection against Parkinson's disease
Genetics February 19,2024
Newly discovered genetic mutation protects against Parkinson's disease and offers hope for new therapies

Newly discovered genetic mutation protects against Parkinson's disease and offers hope for new therapies

by University of Southern CaliforniaCredit: Unsplash/CC0 Public DomainA previously unidentified genetic mutation in a small protein provides significant protection against Parkinson's disease
Genetics February 19,2024
YAP and TAZ: Protein partners identified as potential key for fetal bone development

YAP and TAZ: Protein partners identified as potential key for fetal bone development

by Perelman School of Medicine at the University of PennsylvaniaGraphical abstract. Credit:Developmental Cell(2023). DOI: 10.1016/j.devcel.2023.11.029A pair of proteins, YAP and TAZ,
Genetics February 19,2024
YAP and TAZ: Protein partners identified as potential key for fetal bone development

YAP and TAZ: Protein partners identified as potential key for fetal bone development

by Perelman School of Medicine at the University of PennsylvaniaGraphical abstract. Credit:Developmental Cell(2023). DOI: 10.1016/j.devcel.2023.11.029A pair of proteins, YAP and TAZ,
Genetics February 19,2024
A study of genetics of pericarditis increases understanding of newly approved drug treatment

A study of genetics of pericarditis increases understanding of newly approved drug treatment

by deCODE geneticsRosa B. Thorolfsdottir, scientist at deCODE genetics in Iceland and first author on the paper. Credit: deCODE geneticsSequence variants that protect against pericarditis have been di
Genetics February 19,2024
A study of genetics of pericarditis increases understanding of newly approved drug treatment

A study of genetics of pericarditis increases understanding of newly approved drug treatment

by deCODE geneticsRosa B. Thorolfsdottir, scientist at deCODE genetics in Iceland and first author on the paper. Credit: deCODE geneticsSequence variants that protect against pericarditis have been di
Genetics February 19,2024
Scientists show reprogrammed fat cells support tumor growth

Scientists show reprogrammed fat cells support tumor growth

by German Cancer Research Centera, Quantification of lipid droplets by Oil-Red-O staining in undifferentiated 3T3-L1 and 3T3-L1 induced to differentiate in the presence of regular differentiation
Genetics February 19,2024
Scientists show reprogrammed fat cells support tumor growth

Scientists show reprogrammed fat cells support tumor growth

by German Cancer Research Centera, Quantification of lipid droplets by Oil-Red-O staining in undifferentiated 3T3-L1 and 3T3-L1 induced to differentiate in the presence of regular differentiation
Genetics February 19,2024
Research identifies PLK4 as promising therapeutic target for TP53 mutated acute myeloid leukemia

Research identifies PLK4 as promising therapeutic target for TP53 mutated acute myeloid leukemia

by The University of Hong KongLed by Professor Anskar Leung Yu-hung (centre), HKUMed’s Department of Medicine, School of Clinical Medicine, the research team has identified PLK4 as a novel therap
Genetics February 19,2024
Research identifies PLK4 as promising therapeutic target for TP53 mutated acute myeloid leukemia

Research identifies PLK4 as promising therapeutic target for TP53 mutated acute myeloid leukemia

by The University of Hong KongLed by Professor Anskar Leung Yu-hung (centre), HKUMed’s Department of Medicine, School of Clinical Medicine, the research team has identified PLK4 as a novel therap
Genetics February 19,2024
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