New epigenetic markers for prostate cancer discovered

byGarvan Institute of Medical ResearchHistopathological image of a high grade prostate cancer. Credit: Prof James KenchNew epigenetic biomarkers to predict more aggressive forms of prostate canc

Oncology December 21,2023

New epigenetic markers for prostate cancer discovered

byGarvan Institute of Medical ResearchHistopathological image of a high grade prostate cancer. Credit: Prof James KenchNew epigenetic biomarkers to predict more aggressive forms of prostate canc

Oncology December 21,2023

Corrupt endothelial cells found to protect blood cancer cells from chemotherapy

byWeill Cornell Medical CollegePatient-derived-tumor-xenograft (PDX) as models of high-risk T-ALL patients. (A) Schematic representation of the generation and expansion of T-ALL PDX models. PB:

Oncology December 21,2023

Corrupt endothelial cells found to protect blood cancer cells from chemotherapy

byWeill Cornell Medical CollegePatient-derived-tumor-xenograft (PDX) as models of high-risk T-ALL patients. (A) Schematic representation of the generation and expansion of T-ALL PDX models. PB:

Oncology December 21,2023

New potential therapeutic approach for HER2-positive breast cancer discovered

by Leibniz Research Centre for Working Environments and Human Factors in DortmundEDI3 expression and enzyme activity according to HER2 and ER status. A, EDI3 (GPCPD1; 224826_at) mRNA expression was co

Oncology December 21,2023

New potential therapeutic approach for HER2-positive breast cancer discovered

by Leibniz Research Centre for Working Environments and Human Factors in DortmundEDI3 expression and enzyme activity according to HER2 and ER status. A, EDI3 (GPCPD1; 224826_at) mRNA expression was co

Oncology December 21,2023

Discovery suggests new way to target mantle cell lymphoma

byWeill Cornell Medical CollegeThe interaction of two proteins required to regulate expression of key genes in the nucleus of mantle cell lymphoma. The red signals are generated at the interacti

Oncology December 21,2023

Discovery suggests new way to target mantle cell lymphoma

byWeill Cornell Medical CollegeThe interaction of two proteins required to regulate expression of key genes in the nucleus of mantle cell lymphoma. The red signals are generated at the interacti

Oncology December 21,2023

Discovery of a protein controlling resistance to chemotherapy

byUniversité libre de BruxellesEMT is associated with intrinsic resistance to chemotherapy in SCCs. Credit:Nature(2023). DOI: 10.1038/s41586-023-05838-7Despite the recent development

Oncology December 21,2023

Discovery of a protein controlling resistance to chemotherapy

byUniversité libre de BruxellesEMT is associated with intrinsic resistance to chemotherapy in SCCs. Credit:Nature(2023). DOI: 10.1038/s41586-023-05838-7Despite the recent development

Oncology December 21,2023

Discovery of small molecule Gαq/11 protein inhibitors against uveal melanoma

by Compuscript LtdGraphical abstract:Constitutively activated Gαq/11 proteins drive the vast majority of uveal melanoma (UM). GQ262 effectively combats UM both in vitro and in vivo by targeting Gαq/11

Oncology December 21,2023

Discovery of small molecule Gαq/11 protein inhibitors against uveal melanoma

by Compuscript LtdGraphical abstract:Constitutively activated Gαq/11 proteins drive the vast majority of uveal melanoma (UM). GQ262 effectively combats UM both in vitro and in vivo by targeting Gαq/11

Oncology December 21,2023

Marker for therapy response in acute myeloid leukemia identified

byGerman Cancer Research CenterCell line sensitivity and additional patient data. A IC50s for VEN of 19 AML cell lines classified as primitive (Prim-AML, n = 11) or monocytic (Mono-AML, n = 8) t

Oncology December 21,2023

Marker for therapy response in acute myeloid leukemia identified

byGerman Cancer Research CenterCell line sensitivity and additional patient data. A IC50s for VEN of 19 AML cell lines classified as primitive (Prim-AML, n = 11) or monocytic (Mono-AML, n = 8) t

Oncology December 21,2023

Discovery explains cancer chemotherapy resistance, offers solution

byCornell UniversityGraphical abstract. Credit:Molecular Cell(2022). DOI: 10.1016/j.molcel.2022.08.028Researchers have uncovered a novel pathway that explains how cancer cells become

Oncology December 21,2023

Discovery explains cancer chemotherapy resistance, offers solution

byCornell UniversityGraphical abstract. Credit:Molecular Cell(2022). DOI: 10.1016/j.molcel.2022.08.028Researchers have uncovered a novel pathway that explains how cancer cells become

Oncology December 21,2023

Key mechanisms to improve intestinal regeneration and alleviate the side effects of radiotherapy discovered

byThe Spanish National Cancer Research CentreCredit: CC0 Public DomainThe intestine is very susceptible and is affected by the harsh conditions caused by DNA-altering agents, such as radiation a

Gastroenterology December 21,2023

Key mechanisms to improve intestinal regeneration and alleviate the side effects of radiotherapy discovered

byThe Spanish National Cancer Research CentreCredit: CC0 Public DomainThe intestine is very susceptible and is affected by the harsh conditions caused by DNA-altering agents, such as radiation a

Gastroenterology December 21,2023

Recruitment mechanism discovered for cancer-associated fibroblasts in common lung cancer

byUniversity of BarcelonaGenetic models to mimic SMAD2/3 alterations in patient-derived ADC-TAFs and SCC-TAFs. a–c, Fold SMAD3 (a) and SMAD2 (b) mRNA and corresponding ratio (c) in primary lung

Oncology December 21,2023

Recruitment mechanism discovered for cancer-associated fibroblasts in common lung cancer

byUniversity of BarcelonaGenetic models to mimic SMAD2/3 alterations in patient-derived ADC-TAFs and SCC-TAFs. a–c, Fold SMAD3 (a) and SMAD2 (b) mRNA and corresponding ratio (c) in primary lung

Oncology December 21,2023