byAmerican College of Surgeons

Credit: Unsplash/CC0 Public Domain

While mastectomy is often a necessary and life-saving treatment option for many women with breast cancer, the surgery may contribute to worse sexual health, body image, and several other physical and emotional challenges after surgery, according to a new systematic review on the effects of mastectomy in women with breast cancer. Surgeons said the research underscores the importance of screening women before they undergo a mastectomy.

The research will be presented at the American College of Surgeons (ACS)Clinical Congress 2025in Chicago, October 4–7.

"As surgeons, we often focus on the medical side of care. There is no universal or standardized approach to counseling women on the full range of physical and emotional outcomes after mastectomy," said Lauren Raymond-King, MD, lead author of the research and a surgical resident at Yale School of Medicine in New Haven, Connecticut. "As a result, many women go into surgery with an incomplete understanding of what to expect in the long-term, not just physically, but emotionally and psychologically, after undergoing a mastectomy."

Though it is a common procedure, mastectomy, which involves the removal of one or both breasts, is a major surgery that requires long-term follow-up care. More than aquarter of patients with breast cancer typically undergo a mastectomy, and many patients are staying in the hospital for shorter periods after surgery—a trend that prompted the investigators to analyze patients' outcomes after mastectomy through a systematic review.

Out of nearly 3,000 studies they identified, researchers analyzed 20 studies that met their inclusion criteria, examining the effects of mastectomy onquality of life, sexual health, and psychosocial well-being. All the articles focused on the experience of women with stages 1–3 breast cancer. Studies involving women with stage 4 breast cancer, as well as women who elected for a prophylactic mastectomy for cancer risk reduction, were excluded from the study due to the distinct needs and different overall medical decision making for these patients.

"Breast cancer impacts so many patients in our country, and there's constant research being done to improve survival outcomes," said Elizabeth Berger, MD, MS, FACS, senior author of the research and an assistant professor ofsurgeryat Yale School of Medicine. "Now that there are so many more survivors ofbreast cancer, we can't miss the opportunity to study quality of life outcomes for our patients since they are living so much longer after their diagnosis and treatment."

The study is limited by the research included in thesystematic review, which may vary in quality andstudy design, making it difficult to draw conclusions across the studies, the authors noted. Future research will focus on developing a validated screening tool designed to assess the readiness ofwomenfacingmastectomy.

More information: Raymond L, et al. Systematic Review of Psychosocial Outcomes Among Women with Breast Cancer Undergoing Mastectomy, Scientific Forum, American College of Surgeons (ACS) Clinical Congress 2025.

Provided by American College of Surgeons