New screening tool to explore mechanisms behind cancer, autoimmunity and neurodegeneration

by Jelena Pupavac,Wellcome Trust Sanger InstituteA single-cell base editor screen tiling acrossJAK1is improved by coupling genotype with transcriptome.aUMAP of LoF and no

Updated on: April 23,2024

New screening tool to explore mechanisms behind cancer, autoimmunity and neurodegeneration

by Jelena Pupavac,Wellcome Trust Sanger InstituteA single-cell base editor screen tiling acrossJAK1is improved by coupling genotype with transcriptome.aUMAP of LoF and no

Updated on:April 23,2024

Early trial results show benefits of FGFR inhibitors and PARP/ATR inhibitor combinations in multiple tumor types

byUniversity of Texas M. D. Anderson Cancer CenterCredit: Pixabay/CC0 Public DomainResearchers from The University of Texas MD Anderson Cancer Center presented promising findings from multiple c

Updated on: January 29,2024

Early trial results show benefits of FGFR inhibitors and PARP/ATR inhibitor combinations in multiple tumor types

byUniversity of Texas M. D. Anderson Cancer CenterCredit: Pixabay/CC0 Public DomainResearchers from The University of Texas MD Anderson Cancer Center presented promising findings from multiple c

Updated on:January 29,2024

Race and geography linked to different risks of breast cancer treatment delays

byWileyCredit: Unsplash/CC0 Public DomainFor patients with cancer, lengthy delays in treatment can decrease their chances of survival. In an analysis of 2004–2017 information on patients with br

Updated on: January 23,2024

Race and geography linked to different risks of breast cancer treatment delays

byWileyCredit: Unsplash/CC0 Public DomainFor patients with cancer, lengthy delays in treatment can decrease their chances of survival. In an analysis of 2004–2017 information on patients with br

Updated on:January 23,2024

Newly developed gene classifier identifies risk of pre-breast cancer progression

byDuke University Medical CenterCohorts and methods outline. Two retrospective study cohorts were generated, consisting of ductal carcinoma in situ (DCIS) patients with either a subsequent ipsil

Updated on: January 13,2024

Newly developed gene classifier identifies risk of pre-breast cancer progression

byDuke University Medical CenterCohorts and methods outline. Two retrospective study cohorts were generated, consisting of ductal carcinoma in situ (DCIS) patients with either a subsequent ipsil

Updated on:January 13,2024

Five-year interval is safe for prostate cancer screening, research shows

by European Association of UrologyCredit: CC0 Public DomainA simple blood test every five years is sufficient to screen low risk men for prostate cancer, new research has shown.The PSA blood test

Updated on: April 06,2024

Five-year interval is safe for prostate cancer screening, research shows

by European Association of UrologyCredit: CC0 Public DomainA simple blood test every five years is sufficient to screen low risk men for prostate cancer, new research has shown.The PSA blood test

Updated on:April 06,2024

Study links mutations in notch gene to role in B cell cancers

by Perelman School of Medicine at the University of PennsylvaniaPeripheral blood with chronic lymphocytic leukemia cells. Credit: Jon Aster, Harvard Medical SchoolNotch is one of the most frequen

Updated on: July 02,2024

Study links mutations in notch gene to role in B cell cancers

by Perelman School of Medicine at the University of PennsylvaniaPeripheral blood with chronic lymphocytic leukemia cells. Credit: Jon Aster, Harvard Medical SchoolNotch is one of the most frequen

Updated on:July 02,2024

Ancient viruses could help kill cancers

by The Francis Crick InstituteHeatmap showing expression of melanoma-specific transcripts across a range of cancer types. The three columns with high expression are from melanoma samples. Credit:

Updated on: March 30,2024

Ancient viruses could help kill cancers

by The Francis Crick InstituteHeatmap showing expression of melanoma-specific transcripts across a range of cancer types. The three columns with high expression are from melanoma samples. Credit:

Updated on:March 30,2024

Drug bypasses suppressive immune cells to unleash immunotherapy

by Marta Wegorzewska,Washington University School of MedicineImmunobiologists Robert Schreiber, Ph.D., (left) and Hussein Sultan, Ph.D., of Washington University School of Medicine in St. Louis,

Updated on: August 28,2024

Drug bypasses suppressive immune cells to unleash immunotherapy

by Marta Wegorzewska,Washington University School of MedicineImmunobiologists Robert Schreiber, Ph.D., (left) and Hussein Sultan, Ph.D., of Washington University School of Medicine in St. Louis,

Updated on:August 28,2024

Study finds the mechanism used by metastatic cancer cells to infiltrate the liver

by ResearchSEAThe liver sinusoidal endothelial cells (LSECs, beige) surround a blood vessel containing a cancer cell (green). The cancer cell is able to induce the formation of intracellular gaps

Updated on: January 30,2024

Study finds the mechanism used by metastatic cancer cells to infiltrate the liver

by ResearchSEAThe liver sinusoidal endothelial cells (LSECs, beige) surround a blood vessel containing a cancer cell (green). The cancer cell is able to induce the formation of intracellular gaps

Updated on:January 30,2024

Researchers discover cancer hijacks a class of enzyme motif mutations to fuel tumorigenesis

byUniversity of North Carolina at Chapel Hill School of MedicineCredit: Pixabay/CC0 Public DomainCancer spreads throughout the human body in cunning, almost militaristic, ways. For example, it c

Updated on: January 30,2024

Researchers discover cancer hijacks a class of enzyme motif mutations to fuel tumorigenesis

byUniversity of North Carolina at Chapel Hill School of MedicineCredit: Pixabay/CC0 Public DomainCancer spreads throughout the human body in cunning, almost militaristic, ways. For example, it c

Updated on:January 30,2024

Everolimus inhibits angiogenesis and lymphangiogenesis in TP53 mutant HNSCC via STAT3/HIF-1α/VEGF pathway

by Impact Journals LLCEverolimus reduces microvessel density (MVD) and lymphatic vessel density (LVD) in TP53 mutant HNSCC xenografts. Credit:Oncotarget(2023). DOI: 10.18632/oncotarget.283

Updated on: February 03,2024

Everolimus inhibits angiogenesis and lymphangiogenesis in TP53 mutant HNSCC via STAT3/HIF-1α/VEGF pathway

by Impact Journals LLCEverolimus reduces microvessel density (MVD) and lymphatic vessel density (LVD) in TP53 mutant HNSCC xenografts. Credit:Oncotarget(2023). DOI: 10.18632/oncotarget.283

Updated on:February 03,2024

Combination therapy outperforms chemotherapy in clinical trial for patients with chronic lymphocytic leukemia

by University of AmsterdamCredit: Unsplash/CC0 Public DomainChemotherapy has been the most effective treatment to date for young and fit patients with chronic lymphocytic leukemia (CLL). The dise

Updated on: February 03,2024

Combination therapy outperforms chemotherapy in clinical trial for patients with chronic lymphocytic leukemia

by University of AmsterdamCredit: Unsplash/CC0 Public DomainChemotherapy has been the most effective treatment to date for young and fit patients with chronic lymphocytic leukemia (CLL). The dise

Updated on:February 03,2024