Soluble immune checkpoint factors in blood as potential biomarkers of therapeutic efficacy for ICI cancer immunotherapy

by Kindai UniversityThe concentration of soluble PD-L1m PD-1, CTLA4 in plasma were highly correlated with the expression of genes associated with exhaustion in the peripheral CD8+T cells. R valu

Updated on: April 06,2024

Soluble immune checkpoint factors in blood as potential biomarkers of therapeutic efficacy for ICI cancer immunotherapy

by Kindai UniversityThe concentration of soluble PD-L1m PD-1, CTLA4 in plasma were highly correlated with the expression of genes associated with exhaustion in the peripheral CD8+T cells. R valu

Updated on:April 06,2024

Stopping a rare childhood cancer in its tracks

byCold Spring Harbor LaboratoryScientists discovered targeting a protein called ETV6 can turn Ewing sarcoma cancer cells back to normal-looking and -behaving connective tissue cells, as seen abo

Updated on: January 22,2024

Stopping a rare childhood cancer in its tracks

byCold Spring Harbor LaboratoryScientists discovered targeting a protein called ETV6 can turn Ewing sarcoma cancer cells back to normal-looking and -behaving connective tissue cells, as seen abo

Updated on:January 22,2024

APC protein affects colon cancer immunity by preventing pre-cancerous inflammation

by Institut PasteurHuman T lymphocytes expressing or lacking APC. Lack of APC impairs microtubule cytoskeleton organization (green filaments). Credit: Institut PasteurAdenomatous polyposis coli (APC)

Updated on: March 06,2024

APC protein affects colon cancer immunity by preventing pre-cancerous inflammation

by Institut PasteurHuman T lymphocytes expressing or lacking APC. Lack of APC impairs microtubule cytoskeleton organization (green filaments). Credit: Institut PasteurAdenomatous polyposis coli (APC)

Updated on:March 06,2024

Expert discusses the deeper complexities of cancer

by University of MichiganCredit: CC0 Public DomainGeeta Mehta studies cancer not simply as masses of cells but as structured organs with multiple cell types that communicate with each other and i

Updated on: April 01,2024

Expert discusses the deeper complexities of cancer

by University of MichiganCredit: CC0 Public DomainGeeta Mehta studies cancer not simply as masses of cells but as structured organs with multiple cell types that communicate with each other and i

Updated on:April 01,2024

Performance in physical tests can help manage treatment for metastatic lung cancer

byFAPESPCredit: Unsplash/CC0 Public DomainA study of patients with metastatic lung cancer by researchers based in Brazil and the United States has found that their performance in simple physical

Updated on: November 09,2024

Performance in physical tests can help manage treatment for metastatic lung cancer

byFAPESPCredit: Unsplash/CC0 Public DomainA study of patients with metastatic lung cancer by researchers based in Brazil and the United States has found that their performance in simple physical

Updated on:November 09,2024

Chemotherapy-resistant ovarian cancer cells protect their neighbors, shows study

by University of PittsburghCredit: Unsplash/CC0 Public DomainCertain chemotherapy-resistant ovarian cancer cells protect neighboring cancer cells by sending signals that induce resistance, accord

Updated on: February 03,2024

Chemotherapy-resistant ovarian cancer cells protect their neighbors, shows study

by University of PittsburghCredit: Unsplash/CC0 Public DomainCertain chemotherapy-resistant ovarian cancer cells protect neighboring cancer cells by sending signals that induce resistance, accord

Updated on:February 03,2024

Epigenetic drugs in the mission to beat rare cancers

by Simon Schmitt,Helmholtz Association of German Research CentresViability, SSTR2 protein levels, and [68Ga]Ga-DOTA-TATE uptake of MPC and MTT cells treated with epigenetic drugs; (A) Sequence o

Updated on: February 20,2024

Epigenetic drugs in the mission to beat rare cancers

by Simon Schmitt,Helmholtz Association of German Research CentresViability, SSTR2 protein levels, and [68Ga]Ga-DOTA-TATE uptake of MPC and MTT cells treated with epigenetic drugs; (A) Sequence o

Updated on:February 20,2024

Knockout of CD5 on CAR T cells shown to boost anti-tumor efficacy

byPerelman School of Medicine at the University of PennsylvaniaCD5 KO enhances CAR T cell cytotoxicity. Credit:Science Immunology(2024). DOI: 10.1126/sciimmunol.adn6509The effectiven

Updated on: August 03,2024

Knockout of CD5 on CAR T cells shown to boost anti-tumor efficacy

byPerelman School of Medicine at the University of PennsylvaniaCD5 KO enhances CAR T cell cytotoxicity. Credit:Science Immunology(2024). DOI: 10.1126/sciimmunol.adn6509The effectiven

Updated on:August 03,2024

Study examines hesitation toward potential changes to bowel cancer surveillance

byFlinders UniversityCredit: Pixabay/CC0 Public DomainAs doctors and researchers discuss whether to push recommended bowel cancer colonoscopy surveillance intervals out beyond five years, new re

Updated on: January 22,2024

Study examines hesitation toward potential changes to bowel cancer surveillance

byFlinders UniversityCredit: Pixabay/CC0 Public DomainAs doctors and researchers discuss whether to push recommended bowel cancer colonoscopy surveillance intervals out beyond five years, new re

Updated on:January 22,2024

Therapeutic and diagnostic functions of one antibody for pancreatic cancer

by Osaka UniversityFig.1: DKK1–CKAP4 signaling and application of the anti-CKAP4 antibody. DKK1 and CKAP4 are overexpressed in cancer cells and the PI3 kinase–AKT pathway is activated, promoting

Updated on: May 20,2024

Therapeutic and diagnostic functions of one antibody for pancreatic cancer

by Osaka UniversityFig.1: DKK1–CKAP4 signaling and application of the anti-CKAP4 antibody. DKK1 and CKAP4 are overexpressed in cancer cells and the PI3 kinase–AKT pathway is activated, promoting

Updated on:May 20,2024

Test can predict how people with leukaemia will respond to chemotherapy

by BloodwiseCredit: CC0 Public DomainThe first test to quickly and accurately predict how people will respond to standard treatment for the most common type of leukaemia has been developed at Cardiff

Updated on: April 18,2024

Test can predict how people with leukaemia will respond to chemotherapy

by BloodwiseCredit: CC0 Public DomainThe first test to quickly and accurately predict how people will respond to standard treatment for the most common type of leukaemia has been developed at Cardiff

Updated on:April 18,2024

Proving the efficacy of local treatment in liver cancer oligometastases

by Korea University College of MedicineThe inclusion process. Credit:Cancers(2023). DOI: 10.3390/cancers15133467Professor Chai Hong Rim of the Department of Radiation Oncology, Korea Unive

Updated on: April 14,2024

Proving the efficacy of local treatment in liver cancer oligometastases

by Korea University College of MedicineThe inclusion process. Credit:Cancers(2023). DOI: 10.3390/cancers15133467Professor Chai Hong Rim of the Department of Radiation Oncology, Korea Unive

Updated on:April 14,2024