How genome doubling helps cancer develop

byEcole Polytechnique Federale de LausanneChromosomes in cells with whole genome doubling. Credit: Elisa Oricchio/Giovanni Ciriello (EPFL/UNIL)A single cell contains 2-3 meters of DNA, meaning t

Updated on: December 25,2023 9

How genome doubling helps cancer develop

byEcole Polytechnique Federale de LausanneChromosomes in cells with whole genome doubling. Credit: Elisa Oricchio/Giovanni Ciriello (EPFL/UNIL)A single cell contains 2-3 meters of DNA, meaning t

Updated on:December 25,2023 9

Colon cancer: Dying cancer cells give neighboring tumor cells instructions on how to survive

by Markus Bernards,Goethe University Frankfurt am MainDying tumor cells induce mTOR survival signaling in a paracrine manner. Credit:Nature(2022). DOI: 10.1038/s41586-022-05426-1Colo

Updated on: December 26,2023 9

Colon cancer: Dying cancer cells give neighboring tumor cells instructions on how to survive

by Markus Bernards,Goethe University Frankfurt am MainDying tumor cells induce mTOR survival signaling in a paracrine manner. Credit:Nature(2022). DOI: 10.1038/s41586-022-05426-1Colo

Updated on:December 26,2023 9

New chemical technology leads to better targeted therapeutics against high-risk leukemia in lab

bySt. Jude Children's Research HospitalCredit: Unsplash/CC0 Public DomainMore-effective therapies are greatly needed for children with the high-risk blood cancer T-cell acute lymphoblastic l

Updated on: January 11,2024 15

New chemical technology leads to better targeted therapeutics against high-risk leukemia in lab

bySt. Jude Children's Research HospitalCredit: Unsplash/CC0 Public DomainMore-effective therapies are greatly needed for children with the high-risk blood cancer T-cell acute lymphoblastic l

Updated on:January 11,2024 15

Inhibition of prmt5 by repurposing market drugs: A fresh therapeutic pathway for cancer treatment

by TranSpreadDevelopment of AlphaLISA HTS screen to identify specific PRMT5 inhibitors. (A) Principle of AlphaLISA technique adapted to HTS. Biotinylated histone H4 (a well-known PRMT5 substrate) was

Updated on: January 04,2024 9

Inhibition of prmt5 by repurposing market drugs: A fresh therapeutic pathway for cancer treatment

by TranSpreadDevelopment of AlphaLISA HTS screen to identify specific PRMT5 inhibitors. (A) Principle of AlphaLISA technique adapted to HTS. Biotinylated histone H4 (a well-known PRMT5 substrate) was

Updated on:January 04,2024 9

A blood sample 24 hours after the start of chemotherapy can predict survival

byUniversity of BergenMass cytometry analysis of early response evaluation by single-cell signaling to profile.aPeripheral blood samples were collected from 32 AML patients treated w

Updated on: December 25,2023 12

A blood sample 24 hours after the start of chemotherapy can predict survival

byUniversity of BergenMass cytometry analysis of early response evaluation by single-cell signaling to profile.aPeripheral blood samples were collected from 32 AML patients treated w

Updated on:December 25,2023 12

Preventing 'identity theft' in prostate cancer cells re-sensitizes them to therapy

byUT Southwestern Medical CenterJAK–STAT signaling is required for Enz resistance in TP53/RB1-deficient mCRPC.a, Heat map representing the significantly changed signaling pathways in LNCaP

Updated on: December 22,2023 15

Preventing 'identity theft' in prostate cancer cells re-sensitizes them to therapy

byUT Southwestern Medical CenterJAK–STAT signaling is required for Enz resistance in TP53/RB1-deficient mCRPC.a, Heat map representing the significantly changed signaling pathways in LNCaP

Updated on:December 22,2023 15

Social determinants of health affect racial disparity in prostate cancer mortality

by Elana GotkineWhen accounting for social determinants of health (SDOH), Black men with prostate cancer have lower prostate cancer-specific mortality (PCSM) than White men, according to a systematic

Updated on: December 26,2023 6

Social determinants of health affect racial disparity in prostate cancer mortality

by Elana GotkineWhen accounting for social determinants of health (SDOH), Black men with prostate cancer have lower prostate cancer-specific mortality (PCSM) than White men, according to a systematic

Updated on:December 26,2023 6

NCI-MATCH: T-DM1 shows promising activity in salivary gland cancer

by ECOG-ACRIN Cancer Research GroupDr. Komal Jhaveri of Memorial Sloan Kettering Cancer Center in New York is the lead researcher for the NCI-MATCH precision medicine clinical trial's treatment ar

Updated on: December 20,2023 18

NCI-MATCH: T-DM1 shows promising activity in salivary gland cancer

by ECOG-ACRIN Cancer Research GroupDr. Komal Jhaveri of Memorial Sloan Kettering Cancer Center in New York is the lead researcher for the NCI-MATCH precision medicine clinical trial's treatment ar

Updated on:December 20,2023 18

Patients in lower-income countries receive less timely cancer diagnoses

byPublic Library of ScienceCredit: Unsplash/CC0 Public DomainThe time it takes a cancer patient to see a doctor, receive a diagnosis and begin treatment can vary greatly depending on the patient

Updated on: December 20,2023 10

Patients in lower-income countries receive less timely cancer diagnoses

byPublic Library of ScienceCredit: Unsplash/CC0 Public DomainThe time it takes a cancer patient to see a doctor, receive a diagnosis and begin treatment can vary greatly depending on the patient

Updated on:December 20,2023 10

Men with low-/intermediate-risk prostate cancer benefit from fewer, higher-dose radiation treatments

byAmerican Society for Radiation OncologyStereotactic body radiation therapy (SBRT) is a safe and effective treatment for men with low- and intermediate-risk prostate cancer, according to a long

Updated on: December 18,2023 23

Men with low-/intermediate-risk prostate cancer benefit from fewer, higher-dose radiation treatments

byAmerican Society for Radiation OncologyStereotactic body radiation therapy (SBRT) is a safe and effective treatment for men with low- and intermediate-risk prostate cancer, according to a long

Updated on:December 18,2023 23

Actin cytoskeleton remodeling protects tumor cells against immune attack

by Luxembourg Institute of HealthConfocal microscopy image. Accumulation of actin filaments (in green) at the immunological synapse of a resistant cancer cell in contact with an NK cell (in red). Cell

Updated on: December 18,2023 10

Actin cytoskeleton remodeling protects tumor cells against immune attack

by Luxembourg Institute of HealthConfocal microscopy image. Accumulation of actin filaments (in green) at the immunological synapse of a resistant cancer cell in contact with an NK cell (in red). Cell

Updated on:December 18,2023 10

More women need to be screened for cervical cancer

by Lesley Young,University of AlbertaCredit: CC0 Public DomainUp to 30 per cent of Canadian women are not being regularly screened for cervical cancer, and the lapse is resulting in unnecessary

Updated on: December 18,2023 21

More women need to be screened for cervical cancer

by Lesley Young,University of AlbertaCredit: CC0 Public DomainUp to 30 per cent of Canadian women are not being regularly screened for cervical cancer, and the lapse is resulting in unnecessary

Updated on:December 18,2023 21