Research reveals functional targets of oncogenic HOXA9 protein in high-risk pediatric leukemia

by St. Jude Children's Research HospitalSchematic diagram summarizing this study. Our work interrogated the transcription factor function of HOXA9 in MLL-r leukemias by targeting HOXA9-bound

Updated on: July 02,2024

Research reveals functional targets of oncogenic HOXA9 protein in high-risk pediatric leukemia

by St. Jude Children's Research HospitalSchematic diagram summarizing this study. Our work interrogated the transcription factor function of HOXA9 in MLL-r leukemias by targeting HOXA9-bound

Updated on:July 02,2024

Mechanism of a breast cancer drug points to a possible new therapy

by Sarah Avery,Duke UniversityThree-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Image created in 2014 by Tom

Updated on: May 20,2024

Mechanism of a breast cancer drug points to a possible new therapy

by Sarah Avery,Duke UniversityThree-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Image created in 2014 by Tom

Updated on:May 20,2024

Shortages of essential medicines for pediatric cancer patients threaten outcomes

by Baylor College of MedicineCredit: CC0 Public DomainShortages of essential chemotherapy drugs for children undergoing cancer treatment has been an increasingly frequent obstacle for patients an

Updated on: March 06,2024

Shortages of essential medicines for pediatric cancer patients threaten outcomes

by Baylor College of MedicineCredit: CC0 Public DomainShortages of essential chemotherapy drugs for children undergoing cancer treatment has been an increasingly frequent obstacle for patients an

Updated on:March 06,2024

Boosting the effects of a particular microRNA may benefit patients with cervical cancer

by WileyHigh grade dysplasia (carcinoma in situ) in the uterine cervix. The abnormal epithelium is extending into a mucus gland to the left of centre. This disease can progress to invasive cancer

Updated on: February 18,2024

Boosting the effects of a particular microRNA may benefit patients with cervical cancer

by WileyHigh grade dysplasia (carcinoma in situ) in the uterine cervix. The abnormal epithelium is extending into a mucus gland to the left of centre. This disease can progress to invasive cancer

Updated on:February 18,2024

An unexpected journey reveals a potent way to attack tumors

by Nancy Fliesler,Children's Hospital BostonSenescence inducer CuSO4, which causes ER stress, activates NKp46- and NKG2D-dependent NK killing, but 4-PBA, which induces senescence without ER

Updated on: February 23,2024

An unexpected journey reveals a potent way to attack tumors

by Nancy Fliesler,Children's Hospital BostonSenescence inducer CuSO4, which causes ER stress, activates NKp46- and NKG2D-dependent NK killing, but 4-PBA, which induces senescence without ER

Updated on:February 23,2024

Researchers show that using a tumor's own bacteria is a promising anticancer therapy

by Japan Advanced Institute of Science and TechnologyA bacterial consortium consisting of A-gyo, UN-gyo, and AUN has high anticancer efficacy, triggering the immune system to attack tumor cells. Credi

Updated on: February 24,2024

Researchers show that using a tumor's own bacteria is a promising anticancer therapy

by Japan Advanced Institute of Science and TechnologyA bacterial consortium consisting of A-gyo, UN-gyo, and AUN has high anticancer efficacy, triggering the immune system to attack tumor cells. Credi

Updated on:February 24,2024

South Florida girl in need of rare blood to fight cancer

Credit: CC0 Public DomainA worldwide search is on to find blood donors with a rare genetic variation to help save a 2-year-old South Florida girl battling cancer.Zainab Mughal has neuroblastoma and ne

Updated on: March 12,2024

South Florida girl in need of rare blood to fight cancer

Credit: CC0 Public DomainA worldwide search is on to find blood donors with a rare genetic variation to help save a 2-year-old South Florida girl battling cancer.Zainab Mughal has neuroblastoma and ne

Updated on:March 12,2024

Pancreatic cancer's addiction could be its end

by Cold Spring Harbor LaboratoryThe researchers looked for various indicators of tumor activity in normal pancreas cells (top row) comparing results to those from when the production of the P63 p

Updated on: May 13,2024

Pancreatic cancer's addiction could be its end

by Cold Spring Harbor LaboratoryThe researchers looked for various indicators of tumor activity in normal pancreas cells (top row) comparing results to those from when the production of the P63 p

Updated on:May 13,2024

Factors predict low BMD in pediatric blood cancer survivors

Low bone mineral density (BMD) is common in childhood leukemia and lymphoma survivors, according to a study published online Sept. 19 inCancer.Hadley M. Bloomhardt, M.D., from the Yale School of

Updated on: May 11,2024

Factors predict low BMD in pediatric blood cancer survivors

Low bone mineral density (BMD) is common in childhood leukemia and lymphoma survivors, according to a study published online Sept. 19 inCancer.Hadley M. Bloomhardt, M.D., from the Yale School of

Updated on:May 11,2024

Moving the needle on monitoring skin cancer

by Benjamin Boettner,Harvard UniversityThe team engineered a strategy for monitoring the immunological responses to a newly devised, locally applied immunotherapy against melanoma. The therapy a

Updated on: February 01,2024

Moving the needle on monitoring skin cancer

by Benjamin Boettner,Harvard UniversityThe team engineered a strategy for monitoring the immunological responses to a newly devised, locally applied immunotherapy against melanoma. The therapy a

Updated on:February 01,2024

Novel immune inhibitor associated with glioma progression

by Melissa Rohman,Northwestern UniversityCAFs are enriched in pediatric HGG relative to LGG and NB. (A) UMAP clustering from 21 pediatric brain samples . (B) The frequency of CAFs is a function

Updated on: March 30,2024

Novel immune inhibitor associated with glioma progression

by Melissa Rohman,Northwestern UniversityCAFs are enriched in pediatric HGG relative to LGG and NB. (A) UMAP clustering from 21 pediatric brain samples . (B) The frequency of CAFs is a function

Updated on:March 30,2024

Study uncovers epigenetic source of resistance to targeted therapy in EGFR-mutant lung cancer

by Dana-Farber Cancer InstituteCredit:Cancer Cell(2023). DOI: 10.1016/j.ccell.2023.07.005When lung cancers driven by mutations in the EGFR gene become resistant to osimertinib or othe

Updated on: February 01,2024

Study uncovers epigenetic source of resistance to targeted therapy in EGFR-mutant lung cancer

by Dana-Farber Cancer InstituteCredit:Cancer Cell(2023). DOI: 10.1016/j.ccell.2023.07.005When lung cancers driven by mutations in the EGFR gene become resistant to osimertinib or othe

Updated on:February 01,2024