Research raises hopes for new treatment of fusion-driven cancer

by Aarhus UniversityFusion-gene disruption strategy.ADual intron-targeting CRISPR-Cas9-mediated disruption ofRUNX1-RUNX1T1. sgRNAs targeting intron 4 ofRUNX1(orange)

Updated on: February 03,2024

Research raises hopes for new treatment of fusion-driven cancer

by Aarhus UniversityFusion-gene disruption strategy.ADual intron-targeting CRISPR-Cas9-mediated disruption ofRUNX1-RUNX1T1. sgRNAs targeting intron 4 ofRUNX1(orange)

Updated on:February 03,2024

Novel checklist for 'quality of life' to take cancer clinical trials to the next level

byEuropean Society for Medical OncologyCredit:Annals of Oncology(2022). DOI: 10.1016/j.annonc.2022.12.004The European Society for Medical Oncology (ESMO) has developed a quality of l

Updated on: January 11,2024

Novel checklist for 'quality of life' to take cancer clinical trials to the next level

byEuropean Society for Medical OncologyCredit:Annals of Oncology(2022). DOI: 10.1016/j.annonc.2022.12.004The European Society for Medical Oncology (ESMO) has developed a quality of l

Updated on:January 11,2024

Killing pancreatic cancer with T cells that supercharge themselves

by University of California, San FranciscoTherapeutic T cells engineered with tumor-triggered IL-2 production infiltrate and clear immune-excluded tumors. (A) We hypothesized that cell autonomous

Updated on: February 18,2024

Killing pancreatic cancer with T cells that supercharge themselves

by University of California, San FranciscoTherapeutic T cells engineered with tumor-triggered IL-2 production infiltrate and clear immune-excluded tumors. (A) We hypothesized that cell autonomous

Updated on:February 18,2024

Repurposing existing FDA-approved inhibitors may provide new treatment approach for ovarian cancer

by The Wistar InstituteCredit: The Wistar InstituteWistar researchers have found rationale for repurposing a class of antitumor compounds called HDAC inhibitors, already approved by the FDA for t

Updated on: April 07,2024

Repurposing existing FDA-approved inhibitors may provide new treatment approach for ovarian cancer

by The Wistar InstituteCredit: The Wistar InstituteWistar researchers have found rationale for repurposing a class of antitumor compounds called HDAC inhibitors, already approved by the FDA for t

Updated on:April 07,2024

Researchers show potential liver cancer treatment by targeting cancer stem-like cells

by National University of SingaporeLiver cancer stem-like cells grown as tumourspheres that are sensitive to JAK/STAT small molecule inhibitors. Credit: National University of SingaporeLiver canc

Updated on: March 01,2024

Researchers show potential liver cancer treatment by targeting cancer stem-like cells

by National University of SingaporeLiver cancer stem-like cells grown as tumourspheres that are sensitive to JAK/STAT small molecule inhibitors. Credit: National University of SingaporeLiver canc

Updated on:March 01,2024

New prognostic biomarker identified in small cell lung cancer

byChinese Academy of SciencesGraphical abstract. Credit:iScience(2024). DOI: 10.1016/j.isci.2024.110413Small cell lung cancer (SCLC) is a fast-growing and highly malignant subtype of

Updated on: September 10,2024

New prognostic biomarker identified in small cell lung cancer

byChinese Academy of SciencesGraphical abstract. Credit:iScience(2024). DOI: 10.1016/j.isci.2024.110413Small cell lung cancer (SCLC) is a fast-growing and highly malignant subtype of

Updated on:September 10,2024

Genetic test could help fight secondary breast cancer

by University of SheffieldMammograms showing a normal breast (left) and a breast with cancer (right). Credit: Public DomainThousands of breast cancer patients at risk of developing aggressive sec

Updated on: March 01,2024

Genetic test could help fight secondary breast cancer

by University of SheffieldMammograms showing a normal breast (left) and a breast with cancer (right). Credit: Public DomainThousands of breast cancer patients at risk of developing aggressive sec

Updated on:March 01,2024

Study: Breast cancer disparity equally impacted by social determinants of health, tumor biology

by University of Illinois at ChicagoCredit: Unsplash/CC0 Public DomainResearchers at the University of Illinois Chicago have examined national data about women with early-stage, estrogen receptor

Updated on: February 01,2024

Study: Breast cancer disparity equally impacted by social determinants of health, tumor biology

by University of Illinois at ChicagoCredit: Unsplash/CC0 Public DomainResearchers at the University of Illinois Chicago have examined national data about women with early-stage, estrogen receptor

Updated on:February 01,2024

Researchers find superantigen mutant can trigger immune response in ovarian cancer cells

by Liu Jia,Chinese Academy of SciencesThe transwell co-culture models of transcriptome experiment. Credit:International Journal of Molecular Sciences(2023). DOI: 10.3390/ijms24141179

Updated on: January 30,2024

Researchers find superantigen mutant can trigger immune response in ovarian cancer cells

by Liu Jia,Chinese Academy of SciencesThe transwell co-culture models of transcriptome experiment. Credit:International Journal of Molecular Sciences(2023). DOI: 10.3390/ijms24141179

Updated on:January 30,2024

Research provides critical information about size and growth speed of gliomas

by Kelley Luckstein,Mayo ClinicCredit: Mayo ClinicAn important new clue for preventing and treating brain tumors known as gliomas has been identified in research led by the Lunenfeld-Tannenbaum

Updated on: January 30,2024

Research provides critical information about size and growth speed of gliomas

by Kelley Luckstein,Mayo ClinicCredit: Mayo ClinicAn important new clue for preventing and treating brain tumors known as gliomas has been identified in research led by the Lunenfeld-Tannenbaum

Updated on:January 30,2024

Stress granules may drive obesity-associated pancreatic cancer

byThomas Jefferson UniversityCredit: Pixabay/CC0 Public DomainObesity is a known risk factor for at least13 types of cancer, in part because it creates ever-present inflammatory state. For

Updated on: January 16,2024

Stress granules may drive obesity-associated pancreatic cancer

byThomas Jefferson UniversityCredit: Pixabay/CC0 Public DomainObesity is a known risk factor for at least13 types of cancer, in part because it creates ever-present inflammatory state. For

Updated on:January 16,2024

Research unveils genetic characteristics and improved prognosis of triple-negative apocrine carcinoma

by JooHyeon Heo,Ulsan National Institute of Science and TechnologySomatic Point Mutations in TNAC and LK-TNBC. The top 16 significantly mutated genes as determined by the dNdScv algorithm (p &lt

Updated on: February 18,2024

Research unveils genetic characteristics and improved prognosis of triple-negative apocrine carcinoma

by JooHyeon Heo,Ulsan National Institute of Science and TechnologySomatic Point Mutations in TNAC and LK-TNBC. The top 16 significantly mutated genes as determined by the dNdScv algorithm (p &lt

Updated on:February 18,2024