Supercharging CAR-T cells for cancer treatment

byEcole Polytechnique Federale de LausanneIL-10-expressing CAR T cells counter dysfunction in tumors.a, Schematic depicting the HER2 CAR and IL-10 HER2 CAR constructs; scFv, single-chain v

Updated on: January 26,2024

Supercharging CAR-T cells for cancer treatment

byEcole Polytechnique Federale de LausanneIL-10-expressing CAR T cells counter dysfunction in tumors.a, Schematic depicting the HER2 CAR and IL-10 HER2 CAR constructs; scFv, single-chain v

Updated on:January 26,2024

Viagra could help treat oxygen-deprived newborns, clinical trial finds

by McGill University Health CentreEvolution over time of brain MRI of 2 neonates with NE with severe near-total brain injury despite TH, when treated with TH and placebo (top) and when treated wi

Updated on: May 26,2024

Viagra could help treat oxygen-deprived newborns, clinical trial finds

by McGill University Health CentreEvolution over time of brain MRI of 2 neonates with NE with severe near-total brain injury despite TH, when treated with TH and placebo (top) and when treated wi

Updated on:May 26,2024

Researchers testing new brain cancer vaccine

by Rush University Medical CenterGlioblastoma (histology slide). Credit: Wikipedia/CC BY-SA 3.0Rush University Medical Center is part of a new clinical trial testing whether an experimental vacci

Updated on: June 01,2024

Researchers testing new brain cancer vaccine

by Rush University Medical CenterGlioblastoma (histology slide). Credit: Wikipedia/CC BY-SA 3.0Rush University Medical Center is part of a new clinical trial testing whether an experimental vacci

Updated on:June 01,2024

Addition of durvalumab, bevacizumab to TACE beneficial in liver cancer

by Elana GotkineFor patients with embolization-eligible unresectable hepatocellular carcinoma (uHCC), the addition of durvalumab (D) and bevacizumab (B) to transarterial chemoembolization (TACE) impro

Updated on: March 22,2024

Addition of durvalumab, bevacizumab to TACE beneficial in liver cancer

by Elana GotkineFor patients with embolization-eligible unresectable hepatocellular carcinoma (uHCC), the addition of durvalumab (D) and bevacizumab (B) to transarterial chemoembolization (TACE) impro

Updated on:March 22,2024

CAR-T cell researchers optimistic about future of treating blood cancers

by Kelley Luckstein,Mayo ClinicCredit: AI-generated imageSurvival outcomes using chimeric antigen receptor-T cell therapy (CAR-T cell therapy) continue to be impressive for patients with some bl

Updated on: April 09,2024

CAR-T cell researchers optimistic about future of treating blood cancers

by Kelley Luckstein,Mayo ClinicCredit: AI-generated imageSurvival outcomes using chimeric antigen receptor-T cell therapy (CAR-T cell therapy) continue to be impressive for patients with some bl

Updated on:April 09,2024

Genetic discovery could improve treatment of colorectal cancer

by Rémi Carlier,Ecole Polytechnique Federale de LausannePOU5F1B differs from OCT4. a Representative immunofluorescence–confocal microscopy of POU5F1B-HA overexpressing SW480 cells, with DAPI in

Updated on: December 25,2023

Genetic discovery could improve treatment of colorectal cancer

by Rémi Carlier,Ecole Polytechnique Federale de LausannePOU5F1B differs from OCT4. a Representative immunofluorescence–confocal microscopy of POU5F1B-HA overexpressing SW480 cells, with DAPI in

Updated on:December 25,2023

Discovery could lead to 'kinder' treatment for childhood neuroblastoma

by University of CambridgeA ball of neuroblastoma cells forming mature nerves after drug treatment. Credit: Kirsty Ferguson/Developmental CellChildren with neuroblastoma—responsible for 15% of ca

Updated on: March 23,2024

Discovery could lead to 'kinder' treatment for childhood neuroblastoma

by University of CambridgeA ball of neuroblastoma cells forming mature nerves after drug treatment. Credit: Kirsty Ferguson/Developmental CellChildren with neuroblastoma—responsible for 15% of ca

Updated on:March 23,2024

Extreme phenotype approach identifies rare ATR variants as potential male breast cancer susceptibility alleles

by Impact Journals LLCImpact of splicing variants. Credit:Oncotarget(2023). DOI: 10.18632/oncotarget.28358In oncogenetics, some patients could be considered as "extreme phenotypes,&qu

Updated on: December 25,2023

Extreme phenotype approach identifies rare ATR variants as potential male breast cancer susceptibility alleles

by Impact Journals LLCImpact of splicing variants. Credit:Oncotarget(2023). DOI: 10.18632/oncotarget.28358In oncogenetics, some patients could be considered as "extreme phenotypes,&qu

Updated on:December 25,2023

CAR T cell therapy targeting HER2 antigen shows promise against advanced sarcoma in clinical trial

byBaylor College of MedicineCredit: Pixabay/CC0 Public DomainResearchers at Texas Children's Cancer Center and the Center for Cell and Gene Therapy at Baylor College of Medicine, Texas Child

Updated on: April 30,2024

CAR T cell therapy targeting HER2 antigen shows promise against advanced sarcoma in clinical trial

byBaylor College of MedicineCredit: Pixabay/CC0 Public DomainResearchers at Texas Children's Cancer Center and the Center for Cell and Gene Therapy at Baylor College of Medicine, Texas Child

Updated on:April 30,2024

A new therapeutic target turns the immune system against lymphoma

by Ecole Polytechnique Federale de LausanneCredit: CC0 Public DomainNon-Hodgkin's lymphoma (NHL) is a group of cancers that originate in the lymph nodes and affect white blood cells of the im

Updated on: March 25,2024

A new therapeutic target turns the immune system against lymphoma

by Ecole Polytechnique Federale de LausanneCredit: CC0 Public DomainNon-Hodgkin's lymphoma (NHL) is a group of cancers that originate in the lymph nodes and affect white blood cells of the im

Updated on:March 25,2024

Treating Alzheimer's, Parkinson's, type 2 diabetes by eliminating protein aggregation in brain, pancreas

by Steve Martin,Purdue UniversityCredit: Wikimedia CommonsPurdue University researchers have taken the first steps to treat Alzheimer's disease, Parkinson's disease and Type 2 diabetes b

Updated on: May 06,2024

Treating Alzheimer's, Parkinson's, type 2 diabetes by eliminating protein aggregation in brain, pancreas

by Steve Martin,Purdue UniversityCredit: Wikimedia CommonsPurdue University researchers have taken the first steps to treat Alzheimer's disease, Parkinson's disease and Type 2 diabetes b

Updated on:May 06,2024

New hormone therapies before surgery may improve outcomes in high-risk prostate cancer

byWolters Kluwer HealthTime to BCR in the neo-RP and RP cohorts after IPTW. The number of participants at risk are based on unweighted population. Credit:Journal of Urology(2022). DO

Updated on: January 04,2024

New hormone therapies before surgery may improve outcomes in high-risk prostate cancer

byWolters Kluwer HealthTime to BCR in the neo-RP and RP cohorts after IPTW. The number of participants at risk are based on unweighted population. Credit:Journal of Urology(2022). DO

Updated on:January 04,2024