Combination therapy overcomes BET inhibitor resistance, shows study

bySt. Jude Children's Research HospitalStudy first author Shaela Fields (Wright), from the lab of Chunliang, Li, PhD, St. Jude Department of Tumor Cell Biology, led research to understand BE

Updated on: January 16,2024

Combination therapy overcomes BET inhibitor resistance, shows study

bySt. Jude Children's Research HospitalStudy first author Shaela Fields (Wright), from the lab of Chunliang, Li, PhD, St. Jude Department of Tumor Cell Biology, led research to understand BE

Updated on:January 16,2024

Researchers use a new approach to hit an 'undruggable' target

by University of MichiganGraphical abstract. Credit:Nature Chemical Biology(2023). DOI: 10.1038/s41589-022-01248-4The protein STAT5 has long been an appealing target against cancer, b

Updated on: February 18,2024

Researchers use a new approach to hit an 'undruggable' target

by University of MichiganGraphical abstract. Credit:Nature Chemical Biology(2023). DOI: 10.1038/s41589-022-01248-4The protein STAT5 has long been an appealing target against cancer, b

Updated on:February 18,2024

Study brings new understanding of multiple myeloma evolution

by University of Texas M. D. Anderson Cancer CenterGraphical abstract. Credit:Cancer Cell(2023). DOI: 10.1016/j.ccell.2023.05.007A new study by researchers at The University of Texas

Updated on: February 03,2024

Study brings new understanding of multiple myeloma evolution

by University of Texas M. D. Anderson Cancer CenterGraphical abstract. Credit:Cancer Cell(2023). DOI: 10.1016/j.ccell.2023.05.007A new study by researchers at The University of Texas

Updated on:February 03,2024

Certain cancers will likely rise exponentially due to COVID-19 screening delays

byAmerican College of SurgeonsCredit: Unsplash/CC0 Public DomainDelays in cancer screening during the COVID-19 pandemic will likely cause a significant increase in cancer cases that could have b

Updated on: February 18,2024

Certain cancers will likely rise exponentially due to COVID-19 screening delays

byAmerican College of SurgeonsCredit: Unsplash/CC0 Public DomainDelays in cancer screening during the COVID-19 pandemic will likely cause a significant increase in cancer cases that could have b

Updated on:February 18,2024

Tumor macrophage marker offers unique target for treatment

by National Institutes of HealthA nanoparticle attached to CRV (CRV-NP) specifically homed to macrophages in breast tumors in mice (yellow arrow) and did not home to spleen, lung or heart. Nanopa

Updated on: April 09,2024

Tumor macrophage marker offers unique target for treatment

by National Institutes of HealthA nanoparticle attached to CRV (CRV-NP) specifically homed to macrophages in breast tumors in mice (yellow arrow) and did not home to spleen, lung or heart. Nanopa

Updated on:April 09,2024

Using donor CAR T cells shows promise in treating myeloma patients in phase I trial

by Bob Yirka , Medical XpressCAR T Cell Concentrations Stratified by Response. (a) CAR T cell concentrations among ALLO-715 DL3 patients that received any fludarabine/cyclophosphamide/ALLO-647 (FCA) l

Updated on: February 03,2024

Using donor CAR T cells shows promise in treating myeloma patients in phase I trial

by Bob Yirka , Medical XpressCAR T Cell Concentrations Stratified by Response. (a) CAR T cell concentrations among ALLO-715 DL3 patients that received any fludarabine/cyclophosphamide/ALLO-647 (FCA) l

Updated on:February 03,2024

Deadly 'two-faced' protein drives cancer growth, cripples T-cell avengers

by Delthia Ricks , Medical XpressScanning electron micrograph of a human T lymphocyte (also called a T cell) from the immune system of a healthy donor. Credit: NIAIDScientists have deciphered a key st

Updated on: April 09,2024

Deadly 'two-faced' protein drives cancer growth, cripples T-cell avengers

by Delthia Ricks , Medical XpressScanning electron micrograph of a human T lymphocyte (also called a T cell) from the immune system of a healthy donor. Credit: NIAIDScientists have deciphered a key st

Updated on:April 09,2024

Whole-genome study of metastatic tumors provides a catalog of genetic features of metastatic cancer

by Bob Yirka , Medical XpressCredit: CC0 Public DomainA team of researchers with members affiliated with multiple institutions in The Netherlands and Australia has conducted the largest-ever whole-gen

Updated on: March 09,2024

Whole-genome study of metastatic tumors provides a catalog of genetic features of metastatic cancer

by Bob Yirka , Medical XpressCredit: CC0 Public DomainA team of researchers with members affiliated with multiple institutions in The Netherlands and Australia has conducted the largest-ever whole-gen

Updated on:March 09,2024

Researchers identify one driver of melanoma spread

by Amy Mone,Johns Hopkins UniversityCredit: AI-generated imageUsing a small noncoding RNA, microRNA 211, and tools that track the stability and decay of the protein-coding and noncoding RNAs in

Updated on: June 22,2024

Researchers identify one driver of melanoma spread

by Amy Mone,Johns Hopkins UniversityCredit: AI-generated imageUsing a small noncoding RNA, microRNA 211, and tools that track the stability and decay of the protein-coding and noncoding RNAs in

Updated on:June 22,2024

With vibrator used in cell phones, researchers develop 3D tumor spheroids to screen for anti-cancer drugs

by Brigham and Women’s HospitalCredit:Device(2024). DOI: 10.1016/j.device.2024.100255Depending on their location, cancer cells within a three-dimensional (3D) tumor structure can have

Updated on: March 05,2024

With vibrator used in cell phones, researchers develop 3D tumor spheroids to screen for anti-cancer drugs

by Brigham and Women’s HospitalCredit:Device(2024). DOI: 10.1016/j.device.2024.100255Depending on their location, cancer cells within a three-dimensional (3D) tumor structure can have

Updated on:March 05,2024

Researchers identify targeted therapy that can help children with deadly nerve cancer

by The Mount Sinai HospitalCredit: CC0 Public DomainMount Sinai researchers have identified a targeted therapy for adolescent patients with neuroblastoma, a deadly pediatric nerve cancer, who wou

Updated on: June 08,2024

Researchers identify targeted therapy that can help children with deadly nerve cancer

by The Mount Sinai HospitalCredit: CC0 Public DomainMount Sinai researchers have identified a targeted therapy for adolescent patients with neuroblastoma, a deadly pediatric nerve cancer, who wou

Updated on:June 08,2024

Researchers identify potential biomarker to distinguish two aggressive types of brain tumors in children

by Johns Hopkins University School of MedicineSMYD3 overexpression activates the EGFR pathway in CHLA01 cells. (A) Localization of endogenous SMYD3. Representative 60x Z-stack confocal images sho

Updated on: January 30,2024

Researchers identify potential biomarker to distinguish two aggressive types of brain tumors in children

by Johns Hopkins University School of MedicineSMYD3 overexpression activates the EGFR pathway in CHLA01 cells. (A) Localization of endogenous SMYD3. Representative 60x Z-stack confocal images sho

Updated on:January 30,2024