Researchers uncover new targets for breast cancers resistant to standard therapies

by Leslie Cantu,Medical University of South CarolinaSOC therapy commonly induces DNA damage, BRCAness and toxic PARP1 trapping, leading to transcriptional blockage and growth inhibition in ER+ b

Updated on: June 22,2024

Researchers uncover new targets for breast cancers resistant to standard therapies

by Leslie Cantu,Medical University of South CarolinaSOC therapy commonly induces DNA damage, BRCAness and toxic PARP1 trapping, leading to transcriptional blockage and growth inhibition in ER+ b

Updated on:June 22,2024

Many breast cancer survivors may be able to forgo mammograms in old age

by Denise MannOlder breast cancer survivors often have other medical issues and a shorter life expectancy than younger breast cancer survivors. What's more, their cancers are often slow-growing, a

Updated on: January 15,2024

Many breast cancer survivors may be able to forgo mammograms in old age

by Denise MannOlder breast cancer survivors often have other medical issues and a shorter life expectancy than younger breast cancer survivors. What's more, their cancers are often slow-growing, a

Updated on:January 15,2024

Study shows why a common form of immunotherapy fails, and suggests solution

by Georgetown University Medical CenterSamir N. Khleif, MD, director of The Loop Immuno-Oncology Laboratory at Georgetown Lombardi, led the research team that published new research on checkpoint

Updated on: March 01,2024

Study shows why a common form of immunotherapy fails, and suggests solution

by Georgetown University Medical CenterSamir N. Khleif, MD, director of The Loop Immuno-Oncology Laboratory at Georgetown Lombardi, led the research team that published new research on checkpoint

Updated on:March 01,2024

Subtyping of breast cancer cell lines reveals insights into cancer-relevant genes

by Manuela Schüngel, Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbHWaterfall plot depicting recurrent non-synonymous mutations in BC cell lines. Mutations were calle

Updated on: March 30,2024

Subtyping of breast cancer cell lines reveals insights into cancer-relevant genes

by Manuela Schüngel, Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbHWaterfall plot depicting recurrent non-synonymous mutations in BC cell lines. Mutations were calle

Updated on:March 30,2024

New study shows association of historical housing discrimination and shortfalls in colon cancer treatment

by Jeff Hansen,University of Alabama at BirminghamMap of redlining in Birmingham, 1933. Credit: Public domain, Wikimedia CommonsA nationwide study of 196 cities shows that housing discrimination

Updated on: March 30,2024

New study shows association of historical housing discrimination and shortfalls in colon cancer treatment

by Jeff Hansen,University of Alabama at BirminghamMap of redlining in Birmingham, 1933. Credit: Public domain, Wikimedia CommonsA nationwide study of 196 cities shows that housing discrimination

Updated on:March 30,2024

First-line regimens with endocrine therapy show benefits in breast cancer

by Lori SolomonFirst-line regimens with endocrine therapy (ET) may be associated with benefits among patients with human epidermal growth factor receptor 2-positive (ERBB2-positive [formerly HER2-posi

Updated on: February 03,2024

First-line regimens with endocrine therapy show benefits in breast cancer

by Lori SolomonFirst-line regimens with endocrine therapy (ET) may be associated with benefits among patients with human epidermal growth factor receptor 2-positive (ERBB2-positive [formerly HER2-posi

Updated on:February 03,2024

Fatal brake failures: Tumorigenesis in the colon

by Ludwig Maximilian University of MunichMir34a/p53-deficient metastatic colon cancer cells invading into a lymph node. Brown staining detects high levels of nuclear beta-catenin protein, which i

Updated on: March 08,2024

Fatal brake failures: Tumorigenesis in the colon

by Ludwig Maximilian University of MunichMir34a/p53-deficient metastatic colon cancer cells invading into a lymph node. Brown staining detects high levels of nuclear beta-catenin protein, which i

Updated on:March 08,2024

Cancer genes' age and function strongly influence their mutational status

by eLifeCredit: CC0 Public DomainResearchers have provided new insight on why some genes that formed during the evolution of the earliest animals on earth are particularly impaired (or dysregulat

Updated on: April 09,2024

Cancer genes' age and function strongly influence their mutational status

by eLifeCredit: CC0 Public DomainResearchers have provided new insight on why some genes that formed during the evolution of the earliest animals on earth are particularly impaired (or dysregulat

Updated on:April 09,2024

Study shows benefit of universal genetic testing after breast cancer diagnosis

byWalter and Eliza Hall Institute of Medical ResearchClassification of 31 participants found to carry pathogenic gene variants, by gene, estimated risk of having a pathogenic gene variant,* and

Updated on: January 29,2024

Study shows benefit of universal genetic testing after breast cancer diagnosis

byWalter and Eliza Hall Institute of Medical ResearchClassification of 31 participants found to carry pathogenic gene variants, by gene, estimated risk of having a pathogenic gene variant,* and

Updated on:January 29,2024

Study shines light on cancer survival and a key gene mutation

by University of TorontoScientists and doctors have known about the p53 gene for a long time, and that it plays a role in halting tumour growth. Credit: Hush Naidoo via UnsplashUniversity of Toro

Updated on: July 02,2024

Study shines light on cancer survival and a key gene mutation

by University of TorontoScientists and doctors have known about the p53 gene for a long time, and that it plays a role in halting tumour growth. Credit: Hush Naidoo via UnsplashUniversity of Toro

Updated on:July 02,2024

New machine learning model improves prediction of prostate cancer recurrence

byElsevierCredit: Pixabay/CC0 Public DomainPredicting the course of prostate cancer is challenging because only a fraction of prostate cancer patients experience recurrence after radical prostat

Updated on: January 11,2024

New machine learning model improves prediction of prostate cancer recurrence

byElsevierCredit: Pixabay/CC0 Public DomainPredicting the course of prostate cancer is challenging because only a fraction of prostate cancer patients experience recurrence after radical prostat

Updated on:January 11,2024

Tumor mutations may predict response to immunotherapy

by Johns Hopkins University School of MedicineMismatch repair deficiency refers to a characteristic of some cancer cells that create a large number of mutations, or changes, in certain genes when

Updated on: April 07,2024

Tumor mutations may predict response to immunotherapy

by Johns Hopkins University School of MedicineMismatch repair deficiency refers to a characteristic of some cancer cells that create a large number of mutations, or changes, in certain genes when

Updated on:April 07,2024