Double trouble for triple-negative breast cancer: Two-pronged strategy restores immunotherapy sensitivity

by Kimberly McGhee,Medical University of South CarolinaTumor-fighting immune cells in the tumor before (left) and after (right) combination therapy. After combination therapy, many more tumor-fi

Updated on: September 27,2024 0

Double trouble for triple-negative breast cancer: Two-pronged strategy restores immunotherapy sensitivity

by Kimberly McGhee,Medical University of South CarolinaTumor-fighting immune cells in the tumor before (left) and after (right) combination therapy. After combination therapy, many more tumor-fi

Updated on:September 27,2024 0

Researchers overcome treatment resistance mechanism in one of the most aggressive types of breast cancer

by IMIM (Hospital del Mar Medical Research Institute)Stromal traits define resistance to trastuzumab.aPercentage of CD45+ cells in HER2+ BC tumors comparing relapse-free (blue) to relapsin

Updated on: February 03,2024 16

Researchers overcome treatment resistance mechanism in one of the most aggressive types of breast cancer

by IMIM (Hospital del Mar Medical Research Institute)Stromal traits define resistance to trastuzumab.aPercentage of CD45+ cells in HER2+ BC tumors comparing relapse-free (blue) to relapsin

Updated on:February 03,2024 16

Fluidity predicts aggressiveness of cancerous tumors, study

by Leipzig UniversityTumour-associated microscopic effects such as the liquification or increased fluidity of cancer cells have an effect on the tumour’s macroscopic mechanical properties. These

Updated on: January 30,2024 20

Fluidity predicts aggressiveness of cancerous tumors, study

by Leipzig UniversityTumour-associated microscopic effects such as the liquification or increased fluidity of cancer cells have an effect on the tumour’s macroscopic mechanical properties. These

Updated on:January 30,2024 20

Researchers discover deep structural biology connections that help improve CAR therapy

byChildren's Hospital of PhiladelphiaCredit: Nikolaos SgourakisChimeric antigen receptors (CARs) have opened up an exciting new field of therapeutic advancements for rare and difficult-to-tr

Updated on: January 26,2024 11

Researchers discover deep structural biology connections that help improve CAR therapy

byChildren's Hospital of PhiladelphiaCredit: Nikolaos SgourakisChimeric antigen receptors (CARs) have opened up an exciting new field of therapeutic advancements for rare and difficult-to-tr

Updated on:January 26,2024 11

Lymph node-like structures may trigger the demise of cancer tumors

byJohns Hopkins University School of MedicineTertiary lymphoid structure. Credit: Daniel ShuA newly described stage of a lymph node-like structure seen in liver tumors after presurgical immunoth

Updated on: November 11,2024 0

Lymph node-like structures may trigger the demise of cancer tumors

byJohns Hopkins University School of MedicineTertiary lymphoid structure. Credit: Daniel ShuA newly described stage of a lymph node-like structure seen in liver tumors after presurgical immunoth

Updated on:November 11,2024 0

Researchers identify feature of early stage colorectal cancer tumors that signals aggressiveness

by Cheryl Critchley,Monash UniversityOncogenic KRAS-driven MAPK signaling confers tolerance to epithelial TGFβ activation. a Representative H&E and Alk5 ISH of small intestinal tissue from V

Updated on: February 20,2024 19

Researchers identify feature of early stage colorectal cancer tumors that signals aggressiveness

by Cheryl Critchley,Monash UniversityOncogenic KRAS-driven MAPK signaling confers tolerance to epithelial TGFβ activation. a Representative H&E and Alk5 ISH of small intestinal tissue from V

Updated on:February 20,2024 19

Determinants of overall survival in metastatic uveal melanoma identified

by Elana GotkineFactors associated with improved survival in metastatic uveal melanoma include female sex and use of anti‐cytotoxic T lymphocyte-associated antigen (CTLA)‐4 and anti‐programmed cell de

Updated on: January 22,2024 20

Determinants of overall survival in metastatic uveal melanoma identified

by Elana GotkineFactors associated with improved survival in metastatic uveal melanoma include female sex and use of anti‐cytotoxic T lymphocyte-associated antigen (CTLA)‐4 and anti‐programmed cell de

Updated on:January 22,2024 20

Exploring the role of RNA modification in normal hematopoiesis and acute myeloid leukemia pathogenesis

by Cactus CommunicationsThe review sheds light on the role of post-transcriptional RNA modifications in normal hematopoietic development and acute myeloid leukemia, and highlights novel therapeutic ta

Updated on: April 28,2024 0

Exploring the role of RNA modification in normal hematopoiesis and acute myeloid leukemia pathogenesis

by Cactus CommunicationsThe review sheds light on the role of post-transcriptional RNA modifications in normal hematopoietic development and acute myeloid leukemia, and highlights novel therapeutic ta

Updated on:April 28,2024 0

Study: Biomarker in urine may offer noninvasive detection of prostate cancer

by Henry Ford Health SystemNallasivam Palanisamy, Ph.D., associate scientist in the Vattikuti Urology Institute at Henry Ford Health System, examines prostate cancer cells. Credit: Henry Ford Hea

Updated on: March 01,2024 12

Study: Biomarker in urine may offer noninvasive detection of prostate cancer

by Henry Ford Health SystemNallasivam Palanisamy, Ph.D., associate scientist in the Vattikuti Urology Institute at Henry Ford Health System, examines prostate cancer cells. Credit: Henry Ford Hea

Updated on:March 01,2024 12

Blocking DNA production in cancer therapy by targeting the POLtheta enzyme

by Austrian Academy of SciencesGraphical abstract. Credit:Cell Reports(2022). DOI: 10.1016/j.celrep.2022.111716BRCA1 (BReast CAncer Gene 1), a key gene that becomes faulty in some instance

Updated on: January 07,2024 9

Blocking DNA production in cancer therapy by targeting the POLtheta enzyme

by Austrian Academy of SciencesGraphical abstract. Credit:Cell Reports(2022). DOI: 10.1016/j.celrep.2022.111716BRCA1 (BReast CAncer Gene 1), a key gene that becomes faulty in some instance

Updated on:January 07,2024 9

Researchers discover how bacteria make pancreatic cancer cells grow and move

by Virginia TechPancreatic cancer cells (blue) growing as a sphere encased in membranes (red). Credit: National Cancer InstituteVirginia Tech researchers from the Department of Biomedical Enginee

Updated on: January 30,2024 13

Researchers discover how bacteria make pancreatic cancer cells grow and move

by Virginia TechPancreatic cancer cells (blue) growing as a sphere encased in membranes (red). Credit: National Cancer InstituteVirginia Tech researchers from the Department of Biomedical Enginee

Updated on:January 30,2024 13

Researchers discover molecular fail-safe that keeps bladder tissues from turning cancerous

by Fred Hutchinson Cancer CenterCredit: Pixabay/CC0 Public DomainOver the decades, scientists have revealed many strategies our cells use to keep normal cells from becoming cancerous. Now, Fred H

Updated on: January 30,2024 11

Researchers discover molecular fail-safe that keeps bladder tissues from turning cancerous

by Fred Hutchinson Cancer CenterCredit: Pixabay/CC0 Public DomainOver the decades, scientists have revealed many strategies our cells use to keep normal cells from becoming cancerous. Now, Fred H

Updated on:January 30,2024 11