The impact of cohesin mutations: Insights into a hidden regulator of alternative splicing in leukemia

by Justin Jackson , Medical XpressCohesin regulates alternative splicing. (A) Flowchart showing the experimental protocol, as detailed in Materials and Methods. (B) Schematic showing five different cl

Updated on: January 02,2024 10

The impact of cohesin mutations: Insights into a hidden regulator of alternative splicing in leukemia

by Justin Jackson , Medical XpressCohesin regulates alternative splicing. (A) Flowchart showing the experimental protocol, as detailed in Materials and Methods. (B) Schematic showing five different cl

Updated on:January 02,2024 10

Brain tumor clinical trial: Failed Alzheimer's drug that boosts effect of radiotherapy to be tested in humans this year

by Worldwide Cancer ResearchFlow chart with the design of a clinical trial with azeliragon in combination with radiotherapy in patients with brain metastases from non-small-cell lung cancer, breast ca

Updated on: January 02,2024 9

Brain tumor clinical trial: Failed Alzheimer's drug that boosts effect of radiotherapy to be tested in humans this year

by Worldwide Cancer ResearchFlow chart with the design of a clinical trial with azeliragon in combination with radiotherapy in patients with brain metastases from non-small-cell lung cancer, breast ca

Updated on:January 02,2024 9

Mechanism identified for drug resistance in glioblastoma brain tumors

by Sarah Avery,Duke UniversityPro-tumor immune programming in the glioma microenvironment is CaMKK2 dependent. a Schematic depicting scRNA-seq experimental design. n = 4 WT and CaMKK2 KO mice ha

Updated on: January 02,2024 9

Mechanism identified for drug resistance in glioblastoma brain tumors

by Sarah Avery,Duke UniversityPro-tumor immune programming in the glioma microenvironment is CaMKK2 dependent. a Schematic depicting scRNA-seq experimental design. n = 4 WT and CaMKK2 KO mice ha

Updated on:January 02,2024 9

Intraventricular immunovirotherapy: A translational step forward

by Impact JournalsPutative mechanisms of toxicity. Credit:Oncotarget(2023). DOI: 10.18632/oncotarget.28343A new research perspective titled "Intraventricular immunovirotherapy; a tran

Updated on: January 02,2024 9

Intraventricular immunovirotherapy: A translational step forward

by Impact JournalsPutative mechanisms of toxicity. Credit:Oncotarget(2023). DOI: 10.18632/oncotarget.28343A new research perspective titled "Intraventricular immunovirotherapy; a tran

Updated on:January 02,2024 9

Unemployment due to brain or spine cancer is linked to more pain and depression

byAmerican Academy of NeurologyCredit: Pixabay/CC0 Public DomainPeople who are unemployed due to brain or spine cancer may experience more severe symptoms of pain, discomfort, anxiety and depres

Updated on: January 02,2024 10

Unemployment due to brain or spine cancer is linked to more pain and depression

byAmerican Academy of NeurologyCredit: Pixabay/CC0 Public DomainPeople who are unemployed due to brain or spine cancer may experience more severe symptoms of pain, discomfort, anxiety and depres

Updated on:January 02,2024 10

Patients with brain cancer may benefit from treatment to boost white blood cells

by Julia Evangelou Strait,Washington University School of Medicine in St. LouisRadiation-induced lymphopenia correlated with decreased survival in patients with GBM. (A) The consort flow diagram

Updated on: January 02,2024 9

Patients with brain cancer may benefit from treatment to boost white blood cells

by Julia Evangelou Strait,Washington University School of Medicine in St. LouisRadiation-induced lymphopenia correlated with decreased survival in patients with GBM. (A) The consort flow diagram

Updated on:January 02,2024 9

Implanted pump safely delivers chemo straight to brain in patients with brain cancer

byColumbia University Irving Medical CenterMRI scans show that chemotherapy delivered via the pump saturated the area in and around each patient's brain tumor. Top images show the brain befo

Updated on: January 02,2024 6

Implanted pump safely delivers chemo straight to brain in patients with brain cancer

byColumbia University Irving Medical CenterMRI scans show that chemotherapy delivered via the pump saturated the area in and around each patient's brain tumor. Top images show the brain befo

Updated on:January 02,2024 6

Medicaid expansion in Southern states associated with earlier and more comprehensive breast cancer treatment

byAmerican College of SurgeonsCredit: Unsplash/CC0 Public DomainPatients diagnosed with invasive breast cancer in a Southern state that expanded access to Medicaid were more likely to receive tr

Updated on: January 02,2024 8

Medicaid expansion in Southern states associated with earlier and more comprehensive breast cancer treatment

byAmerican College of SurgeonsCredit: Unsplash/CC0 Public DomainPatients diagnosed with invasive breast cancer in a Southern state that expanded access to Medicaid were more likely to receive tr

Updated on:January 02,2024 8

Children with resistant leukemia given CRISPR-edited T cells: Phase 1 study results reported

byUniversity College LondonAn artist’s depiction of a T cell. Credit: NIAIDResearchers at Great Ormond Street Hospital for Children (GOSH) and UCL Great Ormond Street Institute of Child Health (

Updated on: January 02,2024 8

Children with resistant leukemia given CRISPR-edited T cells: Phase 1 study results reported

byUniversity College LondonAn artist’s depiction of a T cell. Credit: NIAIDResearchers at Great Ormond Street Hospital for Children (GOSH) and UCL Great Ormond Street Institute of Child Health (

Updated on:January 02,2024 8

Those with the BRCA1 gene mutation may face greater risk for aggressive cancer caused by asbestos exposure

byNagoya UniversityChrysotile-induced MMs present lower expression levels of Brca1. (A) Immunohistochemistry (IHC) staining of total BRCA1 on MM samples (bar=25 μm; N≧7).

Updated on: January 02,2024 10

Those with the BRCA1 gene mutation may face greater risk for aggressive cancer caused by asbestos exposure

byNagoya UniversityChrysotile-induced MMs present lower expression levels of Brca1. (A) Immunohistochemistry (IHC) staining of total BRCA1 on MM samples (bar=25 μm; N≧7).

Updated on:January 02,2024 10

Better cancer treatment inspired by the foam on your latte

by Jennifer Brown,University of IowaSchematic diagram illustrating how O2-GeMs are fabricated and incorporated into clinically relevant therapies for treatment-refractory tumors, such as MPNSTs.

Updated on: January 02,2024 10

Better cancer treatment inspired by the foam on your latte

by Jennifer Brown,University of IowaSchematic diagram illustrating how O2-GeMs are fabricated and incorporated into clinically relevant therapies for treatment-refractory tumors, such as MPNSTs.

Updated on:January 02,2024 10

How post-feeding breasts bounce back from the brink of death to kick-start milk production

byUniversity of SheffieldDelayed alveolar regression in Rac1−/− glands in involution. (A-D) Carmine staining of whole-mounted mammary glands of WT (A, C) and Rac1−/− (B, D) mice at postlactation

Updated on: January 02,2024 16

How post-feeding breasts bounce back from the brink of death to kick-start milk production

byUniversity of SheffieldDelayed alveolar regression in Rac1−/− glands in involution. (A-D) Carmine staining of whole-mounted mammary glands of WT (A, C) and Rac1−/− (B, D) mice at postlactation

Updated on:January 02,2024 16