Research identifies new way to halt pancreatic cancer invasion by targeting healthy cells

by Queen Mary, University of LondonInhibition of FGFR1 limits invasion in pre-clinical models of PDAC.ARepresentative H&E images of MIA PaCa-2: PS1 organotypics treated with 100 n

Updated on: February 20,2024 14

Research identifies new way to halt pancreatic cancer invasion by targeting healthy cells

by Queen Mary, University of LondonInhibition of FGFR1 limits invasion in pre-clinical models of PDAC.ARepresentative H&E images of MIA PaCa-2: PS1 organotypics treated with 100 n

Updated on:February 20,2024 14

Study reveals root of triple negative breast cancer immunosuppression and chemoresistance

by Hokkaido UniversityIn IL-34-expressing tumors, blood vessels were observed only in the outer layer, whereas in IL-34-deficient tumors, blood vessels were observed in the whole area (modified f

Updated on: February 20,2024 20

Study reveals root of triple negative breast cancer immunosuppression and chemoresistance

by Hokkaido UniversityIn IL-34-expressing tumors, blood vessels were observed only in the outer layer, whereas in IL-34-deficient tumors, blood vessels were observed in the whole area (modified f

Updated on:February 20,2024 20

Study validates first-ever predictive AI biomarker of androgen deprivation therapy benefit in prostate cancer

by University Hospitals Cleveland Medical CenterProstate cancer cells. Credit: NIH Image GalleryData from a new study published inNEJM Evidenceshows promise for personalized use of sh

Updated on: February 20,2024 14

Study validates first-ever predictive AI biomarker of androgen deprivation therapy benefit in prostate cancer

by University Hospitals Cleveland Medical CenterProstate cancer cells. Credit: NIH Image GalleryData from a new study published inNEJM Evidenceshows promise for personalized use of sh

Updated on:February 20,2024 14

Mapping lactylome in hepatocellular carcinoma reveals new mechanisms of metabolic adaptation

by Liu Jia,Chinese Academy of SciencesCredit: Pixabay/CC0 Public DomainLactate, a major product of glycolysis in mammals, is significantly increased in pathological states such as tumors, sepsis

Updated on: February 20,2024 10

Mapping lactylome in hepatocellular carcinoma reveals new mechanisms of metabolic adaptation

by Liu Jia,Chinese Academy of SciencesCredit: Pixabay/CC0 Public DomainLactate, a major product of glycolysis in mammals, is significantly increased in pathological states such as tumors, sepsis

Updated on:February 20,2024 10

Researchers publish consensus statement on patient selection and appropriate use of Lu-177 PSMA-617 radionuclide therapy

by Society of Nuclear Medicine and Molecular ImagingProstate cancer cells. Credit: NIH Image GalleryThe Society of Nuclear Medicine and Molecular Imaging (SNMMI) has issued a new consensus statement t

Updated on: February 20,2024 14

Researchers publish consensus statement on patient selection and appropriate use of Lu-177 PSMA-617 radionuclide therapy

by Society of Nuclear Medicine and Molecular ImagingProstate cancer cells. Credit: NIH Image GalleryThe Society of Nuclear Medicine and Molecular Imaging (SNMMI) has issued a new consensus statement t

Updated on:February 20,2024 14

Epigenetic drugs in the mission to beat rare cancers

by Simon Schmitt,Helmholtz Association of German Research CentresViability, SSTR2 protein levels, and [68Ga]Ga-DOTA-TATE uptake of MPC and MTT cells treated with epigenetic drugs; (A) Sequence o

Updated on: February 20,2024 17

Epigenetic drugs in the mission to beat rare cancers

by Simon Schmitt,Helmholtz Association of German Research CentresViability, SSTR2 protein levels, and [68Ga]Ga-DOTA-TATE uptake of MPC and MTT cells treated with epigenetic drugs; (A) Sequence o

Updated on:February 20,2024 17

Rogue immune cells linked to leukemia found to be a key driver of autoimmune diseases

by Garvan Institute of Medical ResearchA killer T cell (centre) hunting a target cell. Credit: NIH Image GalleryGene variants associated with leukemia can produce "rogue" immune cells t

Updated on: February 20,2024 11

Rogue immune cells linked to leukemia found to be a key driver of autoimmune diseases

by Garvan Institute of Medical ResearchA killer T cell (centre) hunting a target cell. Credit: NIH Image GalleryGene variants associated with leukemia can produce "rogue" immune cells t

Updated on:February 20,2024 11

Some breast cancer patients with high responses to chemotherapy may not need surgery

by University of Texas M. D. Anderson Cancer CenterThree-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Credit:

Updated on: February 20,2024 12

Some breast cancer patients with high responses to chemotherapy may not need surgery

by University of Texas M. D. Anderson Cancer CenterThree-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Credit:

Updated on:February 20,2024 12

Genetic modifications improve the therapeutic efficacy of iPSC-derived CAR-T cells against solid tumors

by Kyoto UniversityThe CAR construct impacts the differentiation of CAR-iPSCs into T-cell lineages. a, Schematic presentation of the CAR constructs 19z, 1928z, 19bbz, 1928bbz and w/oED28z CAR (w/

Updated on: February 20,2024 19

Genetic modifications improve the therapeutic efficacy of iPSC-derived CAR-T cells against solid tumors

by Kyoto UniversityThe CAR construct impacts the differentiation of CAR-iPSCs into T-cell lineages. a, Schematic presentation of the CAR constructs 19z, 1928z, 19bbz, 1928bbz and w/oED28z CAR (w/

Updated on:February 20,2024 19

Researchers reveal key mechanism of natural killer cell dysfunction

by Liu Jia,Chinese Academy of SciencesIntratumoral NK cells lack abundant membrane protrusions. Credit:Nature Immunology(2023). DOI: 10.1038/s41590-023-01462-9A team has revealed the

Updated on: February 20,2024 15

Researchers reveal key mechanism of natural killer cell dysfunction

by Liu Jia,Chinese Academy of SciencesIntratumoral NK cells lack abundant membrane protrusions. Credit:Nature Immunology(2023). DOI: 10.1038/s41590-023-01462-9A team has revealed the

Updated on:February 20,2024 15

Research team develops novel strategy to suppress prostate cancer growth

by Aaron Nieto,Baylor College of MedicineProstate cancer cells. Credit: NIH Image GalleryFinding valuable therapeutic interventions for prostate cancer has long guided the research of Dr. Feng Y

Updated on: February 20,2024 18

Research team develops novel strategy to suppress prostate cancer growth

by Aaron Nieto,Baylor College of MedicineProstate cancer cells. Credit: NIH Image GalleryFinding valuable therapeutic interventions for prostate cancer has long guided the research of Dr. Feng Y

Updated on:February 20,2024 18

COVID-19 booster vaccine doses strengthen immunity in blood cancer patients, shows study

by University of SouthamptonCredit: Pixabay/CC0 Public DomainResearch by the University of Southampton into the effectiveness of COVID-19 vaccines in people with lymphoma has shown that repeated

Updated on: February 20,2024 19

COVID-19 booster vaccine doses strengthen immunity in blood cancer patients, shows study

by University of SouthamptonCredit: Pixabay/CC0 Public DomainResearch by the University of Southampton into the effectiveness of COVID-19 vaccines in people with lymphoma has shown that repeated

Updated on:February 20,2024 19