Drug development advances in beneficial loss-of-function mutation targets validated by human genetics

by Sichuan International Medical Exchange and Promotion AssociationTargets primarily include PCSK9, ANGPTL3, HSD17B13, KHK, ASGR1, GPR75, CIDEB, and INHBE. Drug types primarily include small molecules

Updated on: March 28,2024

Drug development advances in beneficial loss-of-function mutation targets validated by human genetics

by Sichuan International Medical Exchange and Promotion AssociationTargets primarily include PCSK9, ANGPTL3, HSD17B13, KHK, ASGR1, GPR75, CIDEB, and INHBE. Drug types primarily include small molecules

Updated on:March 28,2024

Researchers race to develop Paxlovid replacement

by Andrew Smith,Rutgers UniversityX-ray crystal structure of the covalent inhibitor Jun11313 with SARS-CoV-2 PLproand structure-based design of biarylphenyl SARS-CoV-2 PLproinhibitor

Updated on: January 26,2024

Researchers race to develop Paxlovid replacement

by Andrew Smith,Rutgers UniversityX-ray crystal structure of the covalent inhibitor Jun11313 with SARS-CoV-2 PLproand structure-based design of biarylphenyl SARS-CoV-2 PLproinhibitor

Updated on:January 26,2024

Mechanical engineers develop miniaturized, hydrogel-based electric generators for biomedical devices

by The University of Hong KongThe hydrogel electric generator and its working mechanism. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-45931-7Mechanoelectrical energy conversion offers

Updated on: May 14,2024

Mechanical engineers develop miniaturized, hydrogel-based electric generators for biomedical devices

by The University of Hong KongThe hydrogel electric generator and its working mechanism. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-45931-7Mechanoelectrical energy conversion offers

Updated on:May 14,2024

How does HIV get into the cell's center to kickstart infection?

JANUARY 24, 2024 Editors' notesbyUniversity of New South WalesIntact HIV-1 CLPs penetrate Nup98 condensates via FG-binding pocket. Credit:Nature(2024). DOI: 10.1038/s41586-023-06

Updated on: March 14,2024

How does HIV get into the cell's center to kickstart infection?

JANUARY 24, 2024 Editors' notesbyUniversity of New South WalesIntact HIV-1 CLPs penetrate Nup98 condensates via FG-binding pocket. Credit:Nature(2024). DOI: 10.1038/s41586-023-06

Updated on:March 14,2024

Many antibiotic courses for common infections not in line with guidelines

by British Medical JournalCredit: CC0 Public DomainMany antibiotic courses prescribed for common infections treated in English primary care (general practices and community services) exceed the r

Updated on: March 06,2024

Many antibiotic courses for common infections not in line with guidelines

by British Medical JournalCredit: CC0 Public DomainMany antibiotic courses prescribed for common infections treated in English primary care (general practices and community services) exceed the r

Updated on:March 06,2024

Uganda study reports first evidence of resistance to vital antimalarial in children with severe malaria

byLondon School of Hygiene & Tropical MedicineCredit: Unsplash/CC0 Public DomainMutations in malarial parasites linked to artemisinin-resistance in Southeast Asia have now been found in Afri

Updated on: December 04,2024

Uganda study reports first evidence of resistance to vital antimalarial in children with severe malaria

byLondon School of Hygiene & Tropical MedicineCredit: Unsplash/CC0 Public DomainMutations in malarial parasites linked to artemisinin-resistance in Southeast Asia have now been found in Afri

Updated on:December 04,2024

Study supports use of cystic fibrosis drug in infants from four weeks of age

by RCSI University of Medicine and Health SciencesCredit: Pixabay/CC0 Public DomainA cystic fibrosis drug targeting the basic defect that causes the condition has been shown to be safe and effective i

Updated on: April 28,2024

Study supports use of cystic fibrosis drug in infants from four weeks of age

by RCSI University of Medicine and Health SciencesCredit: Pixabay/CC0 Public DomainA cystic fibrosis drug targeting the basic defect that causes the condition has been shown to be safe and effective i

Updated on:April 28,2024

New drug halts growth of aggressive breast cancer in pre-clinical study

FEBRUARY 5, 2024by Jessica Stanley,University of AdelaideCDDD11-8 inhibits proliferation of patient-derived breast organoid models. Credit:Oncogene(2023). DOI: 10.1038/s41388-023-028

Updated on: March 25,2024

New drug halts growth of aggressive breast cancer in pre-clinical study

FEBRUARY 5, 2024by Jessica Stanley,University of AdelaideCDDD11-8 inhibits proliferation of patient-derived breast organoid models. Credit:Oncogene(2023). DOI: 10.1038/s41388-023-028

Updated on:March 25,2024

FastGlioma: The AI Model Transforming Glioma Surgery

Powered by artificial intelligence (AI), FastGlioma offers a new level of precision and efficiency in tumor detection, holding the potential to revolutionize glioma surgery.

Updated on: November 22,2024

FastGlioma: The AI Model Transforming Glioma Surgery

Powered by artificial intelligence (AI), FastGlioma offers a new level of precision and efficiency in tumor detection, holding the potential to revolutionize glioma surgery.

Updated on:November 22,2024

New antibiotic slays deadly superbug in early trial

by Robin FosterResearchers report that a new type of antibiotic has proved its mettle against a deadly superbug.Acinetobacter baumannii, abacteriathat goes by the nickname CRAB when it bec

Updated on: January 26,2024

New antibiotic slays deadly superbug in early trial

by Robin FosterResearchers report that a new type of antibiotic has proved its mettle against a deadly superbug.Acinetobacter baumannii, abacteriathat goes by the nickname CRAB when it bec

Updated on:January 26,2024

New data show pembrolizumab improves breast cancer outcomes regardless of age or menopausal status

by European Organisation for Research and Treatment of CancerCredit: Unsplash/CC0 Public DomainNew data from the KEYNOTE-756 phase 3 clinical trial show that adding the immunotherapy drug pembrolizuma

Updated on: March 28,2024

New data show pembrolizumab improves breast cancer outcomes regardless of age or menopausal status

by European Organisation for Research and Treatment of CancerCredit: Unsplash/CC0 Public DomainNew data from the KEYNOTE-756 phase 3 clinical trial show that adding the immunotherapy drug pembrolizuma

Updated on:March 28,2024

Patients regain much weight after stopping new obesity drug: Study

This is an image of a weight scale. Credit: CDC/Debora CartagenaA new generation of obesity drugs often delivers dramatic weight loss, but many patients wonder what happens when they stop treatment.On

Updated on: January 26,2024

Patients regain much weight after stopping new obesity drug: Study

This is an image of a weight scale. Credit: CDC/Debora CartagenaA new generation of obesity drugs often delivers dramatic weight loss, but many patients wonder what happens when they stop treatment.On

Updated on:January 26,2024