Circuit-specific gene therapy brings new hope for treatment of Parkinson's disease

byChinese Academy of SciencesRetrograde AAV selectively targets D1-MSNs and rescues parkinsonian symptoms with chemogenetic modulation. Credit: SIATResearchers from the Shenzhen Institute of Adv

Updated on: March 14,2024

Circuit-specific gene therapy brings new hope for treatment of Parkinson's disease

byChinese Academy of SciencesRetrograde AAV selectively targets D1-MSNs and rescues parkinsonian symptoms with chemogenetic modulation. Credit: SIATResearchers from the Shenzhen Institute of Adv

Updated on:March 14,2024

Researchers reveal mechanisms of alarmin release at an early stage of immune reaction

byLudwig Maximilian University of MunichSchematic of the experimental design; PBMCs, peripheral blood mononuclear cells. Credit:Nature Immunology(2023). DOI: 10.1038/s41590-023-01656

Updated on: January 27,2024

Researchers reveal mechanisms of alarmin release at an early stage of immune reaction

byLudwig Maximilian University of MunichSchematic of the experimental design; PBMCs, peripheral blood mononuclear cells. Credit:Nature Immunology(2023). DOI: 10.1038/s41590-023-01656

Updated on:January 27,2024

Pharmacologic restraint used in 3 percent of pediatric mental health admissions

by Elana GotkineThe use of pharmacologic restraints occurs in 3 percent of hospitalizations for children admitted with a primary mental health diagnosis, according to a study published online Dec. 11

Updated on: January 26,2024

Pharmacologic restraint used in 3 percent of pediatric mental health admissions

by Elana GotkineThe use of pharmacologic restraints occurs in 3 percent of hospitalizations for children admitted with a primary mental health diagnosis, according to a study published online Dec. 11

Updated on:January 26,2024

How the brain develops in unborn babies

byUniversity of MontrealProtein–protein interaction networks for maternal, fetal, and famine genes. Deregulated (A) maternal, (B) fetal, or (C) famine genes were used as a query to obtain physic

Updated on: March 13,2024

How the brain develops in unborn babies

byUniversity of MontrealProtein–protein interaction networks for maternal, fetal, and famine genes. Deregulated (A) maternal, (B) fetal, or (C) famine genes were used as a query to obtain physic

Updated on:March 13,2024

A non-canonical mechanism for RNA damage compartmentalization and daughter cell protection

Updated on: August 08,2024

A non-canonical mechanism for RNA damage compartmentalization and daughter cell protection

Updated on:August 08,2024

Researchers pinpoint issue that could be hampering common chemotherapy drug

by Anika Hazra,University of TorontoGenome-wide CRISPR–Cas9 screens reveal modulators of gemcitabine sensitivity. Credit:Nature Cancer(2024). DOI: 10.1038/s43018-024-00742-zResearche

Updated on: March 28,2024

Researchers pinpoint issue that could be hampering common chemotherapy drug

by Anika Hazra,University of TorontoGenome-wide CRISPR–Cas9 screens reveal modulators of gemcitabine sensitivity. Credit:Nature Cancer(2024). DOI: 10.1038/s43018-024-00742-zResearche

Updated on:March 28,2024

Cell's 'garbage disposal' may have another role: Helping neurons near skin sense the environment

byJohns Hopkins University School of MedicineNeuronal membrane proteasomes are labeled with a red compound and appear in a subset of sensory neurons that are labeled with green compound. Note, n

Updated on: April 28,2024

Cell's 'garbage disposal' may have another role: Helping neurons near skin sense the environment

byJohns Hopkins University School of MedicineNeuronal membrane proteasomes are labeled with a red compound and appear in a subset of sensory neurons that are labeled with green compound. Note, n

Updated on:April 28,2024

Researchers find drugs used to treat type 2 diabetes and obesity reduce alcohol cravings

by Leigh Anne Kelley,Virginia TechFinal optimized clusters. Shown are the final optimized clusters obtained for our sample. (A) a scatterplot visualized by the UMAP model, we see the two UMAP co

Updated on: January 26,2024

Researchers find drugs used to treat type 2 diabetes and obesity reduce alcohol cravings

by Leigh Anne Kelley,Virginia TechFinal optimized clusters. Shown are the final optimized clusters obtained for our sample. (A) a scatterplot visualized by the UMAP model, we see the two UMAP co

Updated on:January 26,2024

Bowel Habits and Brain Power: Unveiling the Hidden Connection

Updated on: July 15,2024

Bowel Habits and Brain Power: Unveiling the Hidden Connection

Updated on:July 15,2024

New research into life-threatening birth defect of the diaphragm

by Birgit Pfeiffer,Leipzig UniversityHypoplastic lungs of human fetuses with CDH have increased macrophage density and up-regulation of inflammatory mediators. Credit:Science Advances&nbsp

Updated on: August 08,2024

New research into life-threatening birth defect of the diaphragm

by Birgit Pfeiffer,Leipzig UniversityHypoplastic lungs of human fetuses with CDH have increased macrophage density and up-regulation of inflammatory mediators. Credit:Science Advances&nbsp

Updated on:August 08,2024

Drug found to extend survival in prostate cancer with genetic mutations

by Melissa Rohman,Northwestern University(A) rPFS for patients with a germline BRCA alteration, (B) rPFS for patients with a somatic BRCA alteration, (C) OS for patients with a germline BRCA alt

Updated on: January 26,2024

Drug found to extend survival in prostate cancer with genetic mutations

by Melissa Rohman,Northwestern University(A) rPFS for patients with a germline BRCA alteration, (B) rPFS for patients with a somatic BRCA alteration, (C) OS for patients with a germline BRCA alt

Updated on:January 26,2024

Blast exposure linked to intestinal problems

by Veterans Affairs Research CommunicationsCredit: Unsplash/CC0 Public DomainA study by New York and Rocky Mountain U.S. Department of Veterans Affairs researchers showed blast exposure can cause inte

Updated on: April 06,2024

Blast exposure linked to intestinal problems

by Veterans Affairs Research CommunicationsCredit: Unsplash/CC0 Public DomainA study by New York and Rocky Mountain U.S. Department of Veterans Affairs researchers showed blast exposure can cause inte

Updated on:April 06,2024