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Hematology&Oncology
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An avatar to study pediatric brain cancer may soon be a reality

An avatar to study pediatric brain cancer may soon be a reality

byUniversity of TrentoA summary of pPDT and pPDXT generation, amplification and biobanking and their use in drug screening and other applications. Credit:Nature Protocols(2026). DOI: 10.1038/s41596-02

An avatar to study pediatric brain cancer may soon be a reality

byUniversity of TrentoA summary of pPDT and pPDXT generation, amplification and biobanking and their use in drug screening and other applications. Credit:Nature Protocols(2026). DOI: 10.1038/s41596-02
uPAR-targeted CAR T cells shrank solid tumors and cleared metastases in mice

uPAR-targeted CAR T cells shrank solid tumors and cleared metastases in mice

byMemorial Sloan Kettering Cancer CenterCredit:Cell(2026). DOI: 10.1016/j.cell.2026.03.002Chimeric antigen receptor T-cell therapy—CAR T for short—has been a major advance in treating blood cancers li

uPAR-targeted CAR T cells shrank solid tumors and cleared metastases in mice

byMemorial Sloan Kettering Cancer CenterCredit:Cell(2026). DOI: 10.1016/j.cell.2026.03.002Chimeric antigen receptor T-cell therapy—CAR T for short—has been a major advance in treating blood cancers li
TYK2 protein suppresses breast cancer metastasis by sensing extracellular stiffness, research finds

TYK2 protein suppresses breast cancer metastasis by sensing extracellular stiffness, research finds

by Miles Martin,University of California - San DiegoIn healthy tissues, seen in the top two panels here, TYK2 (green) is found on the cell membrane and colocalizes with E-cadherin (red), a protein tha

TYK2 protein suppresses breast cancer metastasis by sensing extracellular stiffness, research finds

by Miles Martin,University of California - San DiegoIn healthy tissues, seen in the top two panels here, TYK2 (green) is found on the cell membrane and colocalizes with E-cadherin (red), a protein tha
After allogeneic transplant, VIC-1911 regimen shows low severe GVHD and no relapse

After allogeneic transplant, VIC-1911 regimen shows low severe GVHD and no relapse

byRoswell Park Comprehensive Cancer CenterCredit: Unsplash/CC0 Public DomainResults of a Phase I clinical trial show that patients who undergo a blood stem cell transplant involving a donor have a low

After allogeneic transplant, VIC-1911 regimen shows low severe GVHD and no relapse

byRoswell Park Comprehensive Cancer CenterCredit: Unsplash/CC0 Public DomainResults of a Phase I clinical trial show that patients who undergo a blood stem cell transplant involving a donor have a low
New analytical method reveals how drug combinations act in leukemia

New analytical method reveals how drug combinations act in leukemia

byTampere UniversityCoPISA workflow and possible states for target discovery in combinatorial therapy. Credit:Nature Communications(2026). DOI: 10.1038/s41467-026-70394-3Acute myeloid leukemia (AML) r

New analytical method reveals how drug combinations act in leukemia

byTampere UniversityCoPISA workflow and possible states for target discovery in combinatorial therapy. Credit:Nature Communications(2026). DOI: 10.1038/s41467-026-70394-3Acute myeloid leukemia (AML) r
MetaRing quickly identifies breast cancer drug sensitivity

MetaRing quickly identifies breast cancer drug sensitivity

by Hefei Institutes of Physical Science, Chinese Academy of SciencesSchematic illustration of the MetaRing platform for detecting paclitaxel treatment sensitivity in breast cancer. Credit: HUANG Guang

MetaRing quickly identifies breast cancer drug sensitivity

by Hefei Institutes of Physical Science, Chinese Academy of SciencesSchematic illustration of the MetaRing platform for detecting paclitaxel treatment sensitivity in breast cancer. Credit: HUANG Guang
FDA warns biotech firm over cancer drug claims

FDA warns biotech firm over cancer drug claims

by HealthDay StaffThe U.S. Food and Drug Administration (FDA) has warned a biotech company about claims that its bladder cancer drug could treat and prevent multiple types of cancer.The agency sent a

FDA warns biotech firm over cancer drug claims

by HealthDay StaffThe U.S. Food and Drug Administration (FDA) has warned a biotech company about claims that its bladder cancer drug could treat and prevent multiple types of cancer.The agency sent a
DOCK10 emerges as key trigger of dangerous insulin hypersecretion in rare pancreatic tumors

DOCK10 emerges as key trigger of dangerous insulin hypersecretion in rare pancreatic tumors

byInstitute of Science TokyoThe dedicator of cytokinesis 10 (DOCK10) gene has been identified as a key driver of abnormal insulin secretion in insulinomas, as reported by researchers from Institute of

DOCK10 emerges as key trigger of dangerous insulin hypersecretion in rare pancreatic tumors

byInstitute of Science TokyoThe dedicator of cytokinesis 10 (DOCK10) gene has been identified as a key driver of abnormal insulin secretion in insulinomas, as reported by researchers from Institute of
3 million-cell map shows menopause reshapes breast tissue, possibly raising cancer risk

3 million-cell map shows menopause reshapes breast tissue, possibly raising cancer risk

byUniversity of CambridgeCredit: RDNE Stock project from PexelsScientists have created the most detailed map to date, comprised of over 3 million cells, showing how breast tissue changes as women age—

3 million-cell map shows menopause reshapes breast tissue, possibly raising cancer risk

byUniversity of CambridgeCredit: RDNE Stock project from PexelsScientists have created the most detailed map to date, comprised of over 3 million cells, showing how breast tissue changes as women age—
Study of 11,000 tumors maps 134 DNA damage signatures across 16 cancers

Study of 11,000 tumors maps 134 DNA damage signatures across 16 cancers

byUniversity of ManchesterRelationship between SBS, DBS, ID, CN and SV signatures across cancers. Credit:Nature Genetics(2026). DOI: 10.1038/s41588-025-02474-xA team of cancer genomics scientists from

Study of 11,000 tumors maps 134 DNA damage signatures across 16 cancers

byUniversity of ManchesterRelationship between SBS, DBS, ID, CN and SV signatures across cancers. Credit:Nature Genetics(2026). DOI: 10.1038/s41588-025-02474-xA team of cancer genomics scientists from
WISDOM trial weighs risk-based cancer screening

WISDOM trial weighs risk-based cancer screening

byJustin Jackson, Medical XpressVisual abstract. Credit:JAMA(2025). DOI: 10.1001/jama.2025.24784University of California, San Francisco investigators led WISDOM, a randomized comparison of risk-based

WISDOM trial weighs risk-based cancer screening

byJustin Jackson, Medical XpressVisual abstract. Credit:JAMA(2025). DOI: 10.1001/jama.2025.24784University of California, San Francisco investigators led WISDOM, a randomized comparison of risk-based
Why anti-estrogen therapy fails in ovarian cancer, and how to make it work

Why anti-estrogen therapy fails in ovarian cancer, and how to make it work

by Darien Sutton,The Wistar InstituteMutant p53 interacts with ERα in ovarian cancer. Credit:Genes & Development(2025). DOI: 10.1101/gad.352953.125Scientists at The Wistar Institute have solved a

Why anti-estrogen therapy fails in ovarian cancer, and how to make it work

by Darien Sutton,The Wistar InstituteMutant p53 interacts with ERα in ovarian cancer. Credit:Genes & Development(2025). DOI: 10.1101/gad.352953.125Scientists at The Wistar Institute have solved a