by Clalit Research Institute

Credit: Pixabay/CC0 Public Domain

An Israeli study has identified TRIM63 as a significant genetic contributor to hypertrophic cardiomyopathy (HCM)—the most common hereditary heart disease worldwide. The findings, published in Circulation: Genomic and Precision Medicine, could transform genetic screening and treatment protocols for HCM patients around the globe.

Led by Dr. Noa Ruhrman Shahar of Rabin Medical Center (Beilinson Hospital) and Professor Shay Ben-Shachar of the Clalit Research Institute, the study provides compelling evidence for the gene's role in both causing and increasing susceptibility to HCM.

"This is a life-saving discovery, " said Dr. Ruhrman Shahar. "Recognizing carriers of disease-causing TRIM63 mutations enables early monitoring and intervention, dramatically lowering the risk of severe, even fatal, cardiac events."

Key findings

The study analyzed 107 unrelated HCM patients using advanced exome-based gene panels, drawing from diverse populations including Ashkenazi Jews, Muslim Arabs, and North African and Middle Eastern Jewish communities. The study uncovered:

"These findings provide vital new insight, " said Prof. Ben-Shachar. "Beyond advancing our scientific understanding, they offer a real opportunity to prevent complications in thousands of high-risk patients through personalized care."

Rewriting the genetic playbook

Despite growing evidence, TRIM63 is currently absent from many commercial HCM gene panels, largely due to historical uncertainty surrounding its role. This new research provides strong justification for its immediate inclusion in diagnostic protocols—particularly in high-risk or underrepresented populations.

The study also highlights the advantages of exome-based genetic testing, which allows for ongoing reanalysis and the seamless addition of newly validated genes—offering far greater flexibility than static, gene-specific panels.

Global implications

Incorporating TRIM63 into standard HCM testing could lead to:

"Our findings represent a major step forward in cardiac genetics" concluded Dr. Ruhrman Shahar. "This mutation causes severe cardiomyopathy and should be recognized as a key risk factor for heart dysfunction. We believe these insights will impact millions worldwide, both in diagnosis and in care."

More information: Noa Ruhrman Shahar et al, Mono and Biallelic Variants in TRIM63 Are Frequently Associated With a Unique Form of Hypertrophic Cardiomyopathy, Circulation: Genomic and Precision Medicine (2025). DOI: 10.1161/CIRCGEN.124.004864