Early-onset pediatric atopic dermatitis tied to higher risk for uveitis

Updated on 2025-05-01 00:00:00 0 0

by Lori Solomon

Children with early-onset atopic dermatitis (AD) have an elevated risk for pediatric uveitis, according to a study published online April 3 in JAMA Ophthalmology.

Yung-Yu Chu, M.D., from Chi Mei Medical Center in Tainan City, Taiwan, and colleagues assessed whether the risk for pediatric uveitis is increased in children with early-onset AD versus a matched control population. The analysis included 114, 889 patients with early-onset AD and 114, 889 propensity score-matched controls without AD.

The researchers found that the AD cohort had a higher risk for developing pediatric uveitis versus controls (0.08 versus 0.05%; hazard ratio, 1.92). Similar results were seen among patients without dupilumab use (0.08 versus 0.05%; hazard ratio, 1.77) and those without autoimmune conditions (0.07 versus 0.05%; hazard ratio, 1.52). Patients with severe AD had a higher risk for developing pediatric uveitis versus those with nonsevere AD (0.40 versus 0.08%; hazard ratio, 3.64).

"This cohort study of children with early-onset AD found an elevated risk of pediatric uveitis compared with matched controls, independent of autoimmune conditions or dupilumab use, " the authors write. "These findings support the potential need to consider ophthalmologic monitoring in children with early-onset AD to try to detect and subsequently manage uveitis if it develops."

More information: Yung-Yu Chu et al, Risk of Developing Pediatric Uveitis Among Patients With Early-Onset Atopic Dermatitis, JAMA Ophthalmology (2025). DOI: 10.1001/jamaophthalmol.2025.0366 Journal information: JAMA Ophthalmology

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