Modular chimeric cytokine receptors improve CAR T-cell therapy for solid tumors

bySt. Jude Children's Research HospitalTwo leucine zipper motifs endow ZipRs with constitutive signal transduction.a, Schematic of IL-2 receptor-based Zip2Rs with phosphorylated (p) JA

Updated on: January 26,2024 25

Modular chimeric cytokine receptors improve CAR T-cell therapy for solid tumors

bySt. Jude Children's Research HospitalTwo leucine zipper motifs endow ZipRs with constitutive signal transduction.a, Schematic of IL-2 receptor-based Zip2Rs with phosphorylated (p) JA

Updated on:January 26,2024 25

Antibody-based therapy eliminates circulating tumor cells in mouse models of breast and pancreatic cancer

by Katie Marquedant,Massachusetts General Hospital(A) Schema for the mouse models of neoadjuvant placebo or 23C6 treatment. (B) Tumor volume measurements of 4T1 orthotopic mammary gland tumors i

Updated on: December 25,2023 6

Antibody-based therapy eliminates circulating tumor cells in mouse models of breast and pancreatic cancer

by Katie Marquedant,Massachusetts General Hospital(A) Schema for the mouse models of neoadjuvant placebo or 23C6 treatment. (B) Tumor volume measurements of 4T1 orthotopic mammary gland tumors i

Updated on:December 25,2023 6

Discovery could lead to better treatment for leukemia

by University of Illinois at ChicagoBone marrow aspirate showing acute myeloid leukemia. Several blasts have Auer rods. Credit: WikipediaPrevious research has revealed that patients with acute my

Updated on: April 14,2024 10

Discovery could lead to better treatment for leukemia

by University of Illinois at ChicagoBone marrow aspirate showing acute myeloid leukemia. Several blasts have Auer rods. Credit: WikipediaPrevious research has revealed that patients with acute my

Updated on:April 14,2024 10

A bad influence—the interplay between tumor cells and immune cells

by Huntsman Cancer InstituteCells live in complex communities called microenvironments, where many different types of cells interact with one another. In cancer, the microenvironment is a place where

Updated on: December 18,2023 14

A bad influence—the interplay between tumor cells and immune cells

by Huntsman Cancer InstituteCells live in complex communities called microenvironments, where many different types of cells interact with one another. In cancer, the microenvironment is a place where

Updated on:December 18,2023 14

Cytokine mediates obesity-related factors linked to colorectal cancer

byMary Ann Liebert, IncCredit: Mary Ann Liebert, Inc., publishersA new study describes the mechanistic relationship between the cytokine interleukin-1ß, (IL-1ß) and obesity, showing that when IL

Updated on: December 18,2023 20

Cytokine mediates obesity-related factors linked to colorectal cancer

byMary Ann Liebert, IncCredit: Mary Ann Liebert, Inc., publishersA new study describes the mechanistic relationship between the cytokine interleukin-1ß, (IL-1ß) and obesity, showing that when IL

Updated on:December 18,2023 20

Anti-PF4 Immunothrombosis Absent Proximate Heparin or Adenovirus Vector Vaccine Exposure

February 2024Lara C. Pullen, PhDNew research reveals that patients with thrombocytopenia, thrombosis, and very high D-dimer levels could have platelet-activating vaccine-induced immune thrombocytopeni

Updated on: February 18,2024 15

Anti-PF4 Immunothrombosis Absent Proximate Heparin or Adenovirus Vector Vaccine Exposure

February 2024Lara C. Pullen, PhDNew research reveals that patients with thrombocytopenia, thrombosis, and very high D-dimer levels could have platelet-activating vaccine-induced immune thrombocytopeni

Updated on:February 18,2024 15

Discovery could improve MDS cancer treatment

by Cold Spring Harbor LaboratoryImmature blood cells (stained purple) do not divide into enough functioning red blood cells when defective. Researchers have discovered how to stop the protein sig

Updated on: April 14,2024 15

Discovery could improve MDS cancer treatment

by Cold Spring Harbor LaboratoryImmature blood cells (stained purple) do not divide into enough functioning red blood cells when defective. Researchers have discovered how to stop the protein sig

Updated on:April 14,2024 15

New research finds oral leukemia therapy to work as well as intravenous decitabine

by Hackensack Meridian HealthCredit: Pixabay/CC0 Public DomainResearchers at Hackensack Meridian's John Theurer Cancer Center (JTCC), are part of a published Phase 3 study reporting on the equival

Updated on: March 21,2024 15

New research finds oral leukemia therapy to work as well as intravenous decitabine

by Hackensack Meridian HealthCredit: Pixabay/CC0 Public DomainResearchers at Hackensack Meridian's John Theurer Cancer Center (JTCC), are part of a published Phase 3 study reporting on the equival

Updated on:March 21,2024 15

Researchers make unexpected discovery in how pancreatic cancer spreads

by Alison Satake,Mayo ClinicCredit:Cell Reports(2023). DOI: 10.1016/j.celrep.2023.113042How cancer spreads or metastasizes is a big question for cancer researchers and patients. Mayo

Updated on: December 30,2023 15

Researchers make unexpected discovery in how pancreatic cancer spreads

by Alison Satake,Mayo ClinicCredit:Cell Reports(2023). DOI: 10.1016/j.celrep.2023.113042How cancer spreads or metastasizes is a big question for cancer researchers and patients. Mayo

Updated on:December 30,2023 15

Predicting DCIS upgrade to invasive cancer at breast surgery with ultrafast imaging

by American Roentgen Ray SocietyA) Preoperative breast MRI, initial DCE post-contrast axial fat-saturated T1 axial subtraction image, demonstrates 6 cm clumped enhancement surrounding biopsy clip

Updated on: January 28,2024 16

Predicting DCIS upgrade to invasive cancer at breast surgery with ultrafast imaging

by American Roentgen Ray SocietyA) Preoperative breast MRI, initial DCE post-contrast axial fat-saturated T1 axial subtraction image, demonstrates 6 cm clumped enhancement surrounding biopsy clip

Updated on:January 28,2024 16

Tiny surgical robots could transform detection and treatment of cancers

byUniversity of LeedsRobotic platform for peripheral lung tumor intervention based on magnetic tentacles. Credit: STORM Lab, University of LeedsA tiny robot which can travel deep into the lungs

Updated on: January 08,2024 12

Tiny surgical robots could transform detection and treatment of cancers

byUniversity of LeedsRobotic platform for peripheral lung tumor intervention based on magnetic tentacles. Credit: STORM Lab, University of LeedsA tiny robot which can travel deep into the lungs

Updated on:January 08,2024 12

Researchers reveal most common complications associated with cancer in pregnant women

by Keele UniversityCredit:Mayo Clinic Proceedings(2021). DOI: 10.1016/j.mayocp.2021.03.038A study led by Keele University aims to improve outcomes for pregnant women who are at a high

Updated on: May 23,2024 7

Researchers reveal most common complications associated with cancer in pregnant women

by Keele UniversityCredit:Mayo Clinic Proceedings(2021). DOI: 10.1016/j.mayocp.2021.03.038A study led by Keele University aims to improve outcomes for pregnant women who are at a high

Updated on:May 23,2024 7