Immunotherapy was meant to defeat cancer—what happened to the great promise?

by Jonathan Fisher,The ConversationCredit: Ivan Samkov from PexelsIn 1893, theAmerican Journal of the Medical Sciencesreported on 10 patients whose large and hitherto incurable cance

Updated on: November 10,2024

Immunotherapy was meant to defeat cancer—what happened to the great promise?

by Jonathan Fisher,The ConversationCredit: Ivan Samkov from PexelsIn 1893, theAmerican Journal of the Medical Sciencesreported on 10 patients whose large and hitherto incurable cance

Updated on:November 10,2024

Inhibition of histone deacetylase 2 reduces MDM2 expression and reduces tumor growth in dedifferentiated liposarcoma

by OncotargetElevated HDAC2 mRNA expression is poorly prognostic in DDLPS. (A) mRNA expression of HDAC2 and disease-free survival (DFS) data from 52 subjects with DDLPS from The Cancer Genome Atlas (T

Updated on: May 11,2024

Inhibition of histone deacetylase 2 reduces MDM2 expression and reduces tumor growth in dedifferentiated liposarcoma

by OncotargetElevated HDAC2 mRNA expression is poorly prognostic in DDLPS. (A) mRNA expression of HDAC2 and disease-free survival (DFS) data from 52 subjects with DDLPS from The Cancer Genome Atlas (T

Updated on:May 11,2024

Researchers discover method to 'turn off' mutated melanoma

by Boston University School of MedicineMelanoma in skin biopsy with H&E stain—this case may represent superficial spreading melanoma. Credit: Wikipedia/CC BY-SA 3.0Melanoma is the deadliest f

Updated on: June 22,2024

Researchers discover method to 'turn off' mutated melanoma

by Boston University School of MedicineMelanoma in skin biopsy with H&E stain—this case may represent superficial spreading melanoma. Credit: Wikipedia/CC BY-SA 3.0Melanoma is the deadliest f

Updated on:June 22,2024

Potential therapeutic target for small cell lung cancer discovered

by Melissa Rohman,Northwestern UniversityGraphic model showing how POU2AF2 establishes the poised enhancer via SWI/SNF activity-dependent recruitment of the Polycomb complex in SCLC-P subtype ce

Updated on: April 28,2024

Potential therapeutic target for small cell lung cancer discovered

by Melissa Rohman,Northwestern UniversityGraphic model showing how POU2AF2 establishes the poised enhancer via SWI/SNF activity-dependent recruitment of the Polycomb complex in SCLC-P subtype ce

Updated on:April 28,2024

Researchers determine epigenetic origin of docetaxel-resistant breast cancer

by IDIBELL-Bellvitge Biomedical Research InstituteResearchers at the Bellvitge Biomedical Research Institute (IDIBELL), published today in Molecular Cancer Research a study where they identify me

Updated on: June 08,2024

Researchers determine epigenetic origin of docetaxel-resistant breast cancer

by IDIBELL-Bellvitge Biomedical Research InstituteResearchers at the Bellvitge Biomedical Research Institute (IDIBELL), published today in Molecular Cancer Research a study where they identify me

Updated on:June 08,2024

A deep-learning model may help predict lung cancer survival and outcomes

by American Association for Cancer ResearchLung CA seen on CXR. Credit:CC BY-SA 4.0James Heilman, MD/WikipediaA deep-learning model developed using serial image scans of tumors from p

Updated on: May 20,2024

A deep-learning model may help predict lung cancer survival and outcomes

by American Association for Cancer ResearchLung CA seen on CXR. Credit:CC BY-SA 4.0James Heilman, MD/WikipediaA deep-learning model developed using serial image scans of tumors from p

Updated on:May 20,2024

Cancer in Europe: more cases but fewer deaths

Credit: CC0 Public DomainThe number of cancer cases has continued to rise across Europe, however mortality rates from the disease have fallen, according to the World Health Organization's "Eu

Updated on: March 06,2024

Cancer in Europe: more cases but fewer deaths

Credit: CC0 Public DomainThe number of cancer cases has continued to rise across Europe, however mortality rates from the disease have fallen, according to the World Health Organization's "Eu

Updated on:March 06,2024

The protein behind immunotherapy resistance

byEcole Polytechnique Federale de LausanneTumor with FMRP-deficient cancer cells (in green) being infiltrated and attached by killer (CD8) T cells. Credit: Jeremy Guillot (Hanahan Lab – EPFL).Im

Updated on: January 02,2024

The protein behind immunotherapy resistance

byEcole Polytechnique Federale de LausanneTumor with FMRP-deficient cancer cells (in green) being infiltrated and attached by killer (CD8) T cells. Credit: Jeremy Guillot (Hanahan Lab – EPFL).Im

Updated on:January 02,2024

Scientist identifies gene responsible for spread of prostate cancer

by Caitlin Coyle,Rutgers UniversityAntonina Mitrofanova is a pioneer in the emerging field of biomedical informatics, fighting cancer with big data. Credit: Nick RomanenkoA Rutgers study has fou

Updated on: March 06,2024

Scientist identifies gene responsible for spread of prostate cancer

by Caitlin Coyle,Rutgers UniversityAntonina Mitrofanova is a pioneer in the emerging field of biomedical informatics, fighting cancer with big data. Credit: Nick RomanenkoA Rutgers study has fou

Updated on:March 06,2024

Researchers show that using a tumor's own bacteria is a promising anticancer therapy

by Japan Advanced Institute of Science and TechnologyA bacterial consortium consisting of A-gyo, UN-gyo, and AUN has high anticancer efficacy, triggering the immune system to attack tumor cells. Credi

Updated on: February 24,2024

Researchers show that using a tumor's own bacteria is a promising anticancer therapy

by Japan Advanced Institute of Science and TechnologyA bacterial consortium consisting of A-gyo, UN-gyo, and AUN has high anticancer efficacy, triggering the immune system to attack tumor cells. Credi

Updated on:February 24,2024

Clinical trial of adjuvant therapy combination shows improved recurrence-free survival in liver cancer patients

by SingHealthCredit: Pixabay/CC0 Public DomainAn international randomized controlled trial, advised by a steering committee co-led by a senior clinician-scientist from the National Cancer Centre

Updated on: March 06,2024

Clinical trial of adjuvant therapy combination shows improved recurrence-free survival in liver cancer patients

by SingHealthCredit: Pixabay/CC0 Public DomainAn international randomized controlled trial, advised by a steering committee co-led by a senior clinician-scientist from the National Cancer Centre

Updated on:March 06,2024

New review on p53 biology and reactivation in blood cancers

byKarolinska InstitutetA simplified scheme of p53 regulation in cells upon stress and the drugs currently evaluated in clinical trials for p53 reactivation for improved therapy in MDS and AML. C

Updated on: March 30,2024

New review on p53 biology and reactivation in blood cancers

byKarolinska InstitutetA simplified scheme of p53 regulation in cells upon stress and the drugs currently evaluated in clinical trials for p53 reactivation for improved therapy in MDS and AML. C

Updated on:March 30,2024