Researchers uncover new clues to origins of the most common pediatric kidney cancer

by Children's Hospital Los AngelesSIX2+CITED1+ cells in hFK and WT have different transcriptional signatures. A,B) Periodic acid Schiff (PAS, left, whole image) and H&E (right, close-up i

Updated on: February 20,2024 17

Researchers uncover new clues to origins of the most common pediatric kidney cancer

by Children's Hospital Los AngelesSIX2+CITED1+ cells in hFK and WT have different transcriptional signatures. A,B) Periodic acid Schiff (PAS, left, whole image) and H&E (right, close-up i

Updated on:February 20,2024 17

Researchers find breast cancer protein that could predict chemotherapy sensitivity

by Hunter Medical Research InstituteThree-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Credit: NCI Center for

Updated on: February 20,2024 14

Researchers find breast cancer protein that could predict chemotherapy sensitivity

by Hunter Medical Research InstituteThree-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Credit: NCI Center for

Updated on:February 20,2024 14

Study maps alterations that make melanoma more severe, could lead to better therapies and diagnosis

by André Julião,FAPESPStudy design, resources and methodology. A major aim (steps 1–2) is the discovery and validation of genome-wide methylation alterations associated with the UV mutational si

Updated on: February 20,2024 11

Study maps alterations that make melanoma more severe, could lead to better therapies and diagnosis

by André Julião,FAPESPStudy design, resources and methodology. A major aim (steps 1–2) is the discovery and validation of genome-wide methylation alterations associated with the UV mutational si

Updated on:February 20,2024 11

Computational method used to directly measure tumors shows hypertranscription is ubiquitous across cancers

by Bob Yirka , Medical XpressOverview of RNA output analysis with RNAmp. (A) Hypertranscription occurs when cancer cells elevate their RNA output above normal cell levels (left). Upon RNA extraction f

Updated on: February 20,2024 19

Computational method used to directly measure tumors shows hypertranscription is ubiquitous across cancers

by Bob Yirka , Medical XpressOverview of RNA output analysis with RNAmp. (A) Hypertranscription occurs when cancer cells elevate their RNA output above normal cell levels (left). Upon RNA extraction f

Updated on:February 20,2024 19

Researchers target mutation that leads to pancreatic cancer

by Leslie Cantu,Medical University of South CarolinaCrystal structures of 12D5(K63S) in complex with KRAS(G12D)•GTPγS and with KRAS(G12D)•GDP. (A) A comparison of 12D5(K63S)–KRAS(G12D)•GTPγS (Le

Updated on: February 20,2024 20

Researchers target mutation that leads to pancreatic cancer

by Leslie Cantu,Medical University of South CarolinaCrystal structures of 12D5(K63S) in complex with KRAS(G12D)•GTPγS and with KRAS(G12D)•GDP. (A) A comparison of 12D5(K63S)–KRAS(G12D)•GTPγS (Le

Updated on:February 20,2024 20

COVID-19 booster vaccine doses strengthen immunity in blood cancer patients, shows study

by University of SouthamptonCredit: Pixabay/CC0 Public DomainResearch by the University of Southampton into the effectiveness of COVID-19 vaccines in people with lymphoma has shown that repeated

Updated on: February 20,2024 19

COVID-19 booster vaccine doses strengthen immunity in blood cancer patients, shows study

by University of SouthamptonCredit: Pixabay/CC0 Public DomainResearch by the University of Southampton into the effectiveness of COVID-19 vaccines in people with lymphoma has shown that repeated

Updated on:February 20,2024 19

Research team develops novel strategy to suppress prostate cancer growth

by Aaron Nieto,Baylor College of MedicineProstate cancer cells. Credit: NIH Image GalleryFinding valuable therapeutic interventions for prostate cancer has long guided the research of Dr. Feng Y

Updated on: February 20,2024 18

Research team develops novel strategy to suppress prostate cancer growth

by Aaron Nieto,Baylor College of MedicineProstate cancer cells. Credit: NIH Image GalleryFinding valuable therapeutic interventions for prostate cancer has long guided the research of Dr. Feng Y

Updated on:February 20,2024 18

Researchers reveal key mechanism of natural killer cell dysfunction

by Liu Jia,Chinese Academy of SciencesIntratumoral NK cells lack abundant membrane protrusions. Credit:Nature Immunology(2023). DOI: 10.1038/s41590-023-01462-9A team has revealed the

Updated on: February 20,2024 15

Researchers reveal key mechanism of natural killer cell dysfunction

by Liu Jia,Chinese Academy of SciencesIntratumoral NK cells lack abundant membrane protrusions. Credit:Nature Immunology(2023). DOI: 10.1038/s41590-023-01462-9A team has revealed the

Updated on:February 20,2024 15

Genetic modifications improve the therapeutic efficacy of iPSC-derived CAR-T cells against solid tumors

by Kyoto UniversityThe CAR construct impacts the differentiation of CAR-iPSCs into T-cell lineages. a, Schematic presentation of the CAR constructs 19z, 1928z, 19bbz, 1928bbz and w/oED28z CAR (w/

Updated on: February 20,2024 19

Genetic modifications improve the therapeutic efficacy of iPSC-derived CAR-T cells against solid tumors

by Kyoto UniversityThe CAR construct impacts the differentiation of CAR-iPSCs into T-cell lineages. a, Schematic presentation of the CAR constructs 19z, 1928z, 19bbz, 1928bbz and w/oED28z CAR (w/

Updated on:February 20,2024 19

Some breast cancer patients with high responses to chemotherapy may not need surgery

by University of Texas M. D. Anderson Cancer CenterThree-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Credit:

Updated on: February 20,2024 12

Some breast cancer patients with high responses to chemotherapy may not need surgery

by University of Texas M. D. Anderson Cancer CenterThree-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Credit:

Updated on:February 20,2024 12

Rogue immune cells linked to leukemia found to be a key driver of autoimmune diseases

by Garvan Institute of Medical ResearchA killer T cell (centre) hunting a target cell. Credit: NIH Image GalleryGene variants associated with leukemia can produce "rogue" immune cells t

Updated on: February 20,2024 11

Rogue immune cells linked to leukemia found to be a key driver of autoimmune diseases

by Garvan Institute of Medical ResearchA killer T cell (centre) hunting a target cell. Credit: NIH Image GalleryGene variants associated with leukemia can produce "rogue" immune cells t

Updated on:February 20,2024 11

Epigenetic drugs in the mission to beat rare cancers

by Simon Schmitt,Helmholtz Association of German Research CentresViability, SSTR2 protein levels, and [68Ga]Ga-DOTA-TATE uptake of MPC and MTT cells treated with epigenetic drugs; (A) Sequence o

Updated on: February 20,2024 17

Epigenetic drugs in the mission to beat rare cancers

by Simon Schmitt,Helmholtz Association of German Research CentresViability, SSTR2 protein levels, and [68Ga]Ga-DOTA-TATE uptake of MPC and MTT cells treated with epigenetic drugs; (A) Sequence o

Updated on:February 20,2024 17