Study of immune 'neighborhoods' highlights macrophages as key players in invasive breast cancers

byUniversity of PittsburghCredit: Unsplash/CC0 Public DomainMost immunotherapies, which aim to boost T cell activity, work poorly in treating estrogen receptor-positive (ER+) breast cancer. Targ

Updated on: January 02,2024

Study of immune 'neighborhoods' highlights macrophages as key players in invasive breast cancers

byUniversity of PittsburghCredit: Unsplash/CC0 Public DomainMost immunotherapies, which aim to boost T cell activity, work poorly in treating estrogen receptor-positive (ER+) breast cancer. Targ

Updated on:January 02,2024

HPV vaccine eliminates advanced skin cancer in 97-year-old

(HealthDay)—The 9-valent human papillomavirus (HPV) vaccine could be a therapeutic option for patients with cutaneous squamous cell carcinoma when surgical management is not an option, according to a

Updated on: March 12,2024

HPV vaccine eliminates advanced skin cancer in 97-year-old

(HealthDay)—The 9-valent human papillomavirus (HPV) vaccine could be a therapeutic option for patients with cutaneous squamous cell carcinoma when surgical management is not an option, according to a

Updated on:March 12,2024

New mathematical model shows promising results for prostate cancer treatment

byUniversity of PortsmouthGraphical abstract. Credit:Mathematical Biosciences(2022). DOI: 10.1016/j.mbs.2022.108940A new mathematical model which aims to optimize treatment for prost

Updated on: January 12,2024

New mathematical model shows promising results for prostate cancer treatment

byUniversity of PortsmouthGraphical abstract. Credit:Mathematical Biosciences(2022). DOI: 10.1016/j.mbs.2022.108940A new mathematical model which aims to optimize treatment for prost

Updated on:January 12,2024

Drugmakers are abandoning cheap generics, and now US cancer patients can't get meds, say doctors

by Arthur AllenCredit: CC0 Public DomainOn Nov. 22, three FDA inspectors arrived at the sprawling Intas Pharmaceuticals plant south of Ahmedabad, India, and found hundreds of trash bags full of shredd

Updated on: February 03,2024

Drugmakers are abandoning cheap generics, and now US cancer patients can't get meds, say doctors

by Arthur AllenCredit: CC0 Public DomainOn Nov. 22, three FDA inspectors arrived at the sprawling Intas Pharmaceuticals plant south of Ahmedabad, India, and found hundreds of trash bags full of shredd

Updated on:February 03,2024

Dietary supplement helps combat resistance in breast cancer, finds study

byUniversity of BaselCredit: Unsplash/CC0 Public DomainMany cancer therapies do not produce the hoped-for results. A common reason for this is that the tumors develop resistance to the medicatio

Updated on: January 23,2024

Dietary supplement helps combat resistance in breast cancer, finds study

byUniversity of BaselCredit: Unsplash/CC0 Public DomainMany cancer therapies do not produce the hoped-for results. A common reason for this is that the tumors develop resistance to the medicatio

Updated on:January 23,2024

Illuminating tumor cells with dark proteins

by Columbia UniversityRibosome roadblock effect: comparing the AMD1 tail sequence, poly(A) and the XBP1 stalling sequence. a–e, Reporter constructs shown on the left were transfected into HEK293T

Updated on: February 19,2024

Illuminating tumor cells with dark proteins

by Columbia UniversityRibosome roadblock effect: comparing the AMD1 tail sequence, poly(A) and the XBP1 stalling sequence. a–e, Reporter constructs shown on the left were transfected into HEK293T

Updated on:February 19,2024

New screening tool to explore mechanisms behind cancer, autoimmunity and neurodegeneration

by Jelena Pupavac,Wellcome Trust Sanger InstituteA single-cell base editor screen tiling acrossJAK1is improved by coupling genotype with transcriptome.aUMAP of LoF and no

Updated on: April 23,2024

New screening tool to explore mechanisms behind cancer, autoimmunity and neurodegeneration

by Jelena Pupavac,Wellcome Trust Sanger InstituteA single-cell base editor screen tiling acrossJAK1is improved by coupling genotype with transcriptome.aUMAP of LoF and no

Updated on:April 23,2024

Probing RNA epigenetics and chromatin structures to predict drug resistance in leukemia

by University of Chicago Medical Center5-AZA-sensitive and 5-AZA-resistant leukemia cells have distinctly different chromatin structures. Credit: Jason ChengDrug resistance is a major obstacle to

Updated on: March 09,2024

Probing RNA epigenetics and chromatin structures to predict drug resistance in leukemia

by University of Chicago Medical Center5-AZA-sensitive and 5-AZA-resistant leukemia cells have distinctly different chromatin structures. Credit: Jason ChengDrug resistance is a major obstacle to

Updated on:March 09,2024

AI can predict brain cancer patients' survival

byKing's College LondonCredit: CC0 Public DomainNew research shows that artificial intelligence (AI) can predict whether adult patients with brain cancer will survive more than eight months

Updated on: March 05,2024

AI can predict brain cancer patients' survival

byKing's College LondonCredit: CC0 Public DomainNew research shows that artificial intelligence (AI) can predict whether adult patients with brain cancer will survive more than eight months

Updated on:March 05,2024

Soluble immune checkpoint factors in blood as potential biomarkers of therapeutic efficacy for ICI cancer immunotherapy

by Kindai UniversityThe concentration of soluble PD-L1m PD-1, CTLA4 in plasma were highly correlated with the expression of genes associated with exhaustion in the peripheral CD8+T cells. R valu

Updated on: April 06,2024

Soluble immune checkpoint factors in blood as potential biomarkers of therapeutic efficacy for ICI cancer immunotherapy

by Kindai UniversityThe concentration of soluble PD-L1m PD-1, CTLA4 in plasma were highly correlated with the expression of genes associated with exhaustion in the peripheral CD8+T cells. R valu

Updated on:April 06,2024

Researchers use machine learning to unlock the genomic code in clinical cancer samples

by University of HelsinkiMutational signatures of formalin exposure. a C>T FFPE-only mutation count increases with formalin fixation time. We observed this increase in both unrepaired and repa

Updated on: February 18,2024

Researchers use machine learning to unlock the genomic code in clinical cancer samples

by University of HelsinkiMutational signatures of formalin exposure. a C>T FFPE-only mutation count increases with formalin fixation time. We observed this increase in both unrepaired and repa

Updated on:February 18,2024

An antenna for detecting breast cancer

by David Bradley,InderscienceCredit: CC0 Public DomainBreast cancer is a common illness around the world. It is the most common invasive of cancers in women and affects around one in eight and r

Updated on: March 30,2024

An antenna for detecting breast cancer

by David Bradley,InderscienceCredit: CC0 Public DomainBreast cancer is a common illness around the world. It is the most common invasive of cancers in women and affects around one in eight and r

Updated on:March 30,2024