New insights into the development of Parkinson's disease in the brain might open the doors to new therapies

byTokyo Medical and Dental UniversityIn healthy condition, CHCHD2WT localizes in mitochondria. In pathogenic condition, mutant CHCHD2T61I mislocalizes to the cytosol and recruits Casein kinase 1

Updated on: March 14,2024

New insights into the development of Parkinson's disease in the brain might open the doors to new therapies

byTokyo Medical and Dental UniversityIn healthy condition, CHCHD2WT localizes in mitochondria. In pathogenic condition, mutant CHCHD2T61I mislocalizes to the cytosol and recruits Casein kinase 1

Updated on:March 14,2024

For Alzheimer's patients, a controversial drug brings hope

by Hannah Critchfield and Kirby WilsonCredit: Pixabay/CC0 Public DomainAt 53, Michele Hall was at the height of her legal career. She'd just sent her three kids to college. She had decades ahead w

Updated on: May 26,2024

For Alzheimer's patients, a controversial drug brings hope

by Hannah Critchfield and Kirby WilsonCredit: Pixabay/CC0 Public DomainAt 53, Michele Hall was at the height of her legal career. She'd just sent her three kids to college. She had decades ahead w

Updated on:May 26,2024

Alzheimer's disease could be treated with gene therapy, animal study suggests

by Imperial College LondonBrain cells from a mouse cortex that didn't receive the gene therapy. The amyloid plaques are shown in green, and the glial cells, which surround the plaques, are sh

Updated on: May 22,2024

Alzheimer's disease could be treated with gene therapy, animal study suggests

by Imperial College LondonBrain cells from a mouse cortex that didn't receive the gene therapy. The amyloid plaques are shown in green, and the glial cells, which surround the plaques, are sh

Updated on:May 22,2024

Individuals with high Alzheimer's risk may use attention to process, rather than suppress, distracting stimuli

by California Institute of TechnologyPractice makes imperfect: stronger implicit interference with practice in individuals at high risk of developing Alzheimer’s disease. An example trial sequenc

Updated on: February 24,2024

Individuals with high Alzheimer's risk may use attention to process, rather than suppress, distracting stimuli

by California Institute of TechnologyPractice makes imperfect: stronger implicit interference with practice in individuals at high risk of developing Alzheimer’s disease. An example trial sequenc

Updated on:February 24,2024

Another angle on Alzheimer's: CSF, proteomics, and metabolic enzymes

by Nancy Fliesler,Children's Hospital BostonGraphical abstract. Credit:Cell Reports Medicine(2023). DOI: 10.1016/j.xcrm.2023.101005Currently there are no objective, easily assess

Updated on: April 23,2024

Another angle on Alzheimer's: CSF, proteomics, and metabolic enzymes

by Nancy Fliesler,Children's Hospital BostonGraphical abstract. Credit:Cell Reports Medicine(2023). DOI: 10.1016/j.xcrm.2023.101005Currently there are no objective, easily assess

Updated on:April 23,2024

Better than a hole in the head: Modernizing intracranial pressure sensing methods

by Sara Vaccar,Carnegie Mellon UniversityCredit: Carnegie Mellon UniversityJust as blood pressure informs heart health, intracranial pressure (ICP) helps indicate brain health. ICP sensing is th

Updated on: February 03,2024

Better than a hole in the head: Modernizing intracranial pressure sensing methods

by Sara Vaccar,Carnegie Mellon UniversityCredit: Carnegie Mellon UniversityJust as blood pressure informs heart health, intracranial pressure (ICP) helps indicate brain health. ICP sensing is th

Updated on:February 03,2024

Hippocampus uses dual pathways for memory storage

byRIKENOverview and motivation. Credit:Nature Communications(2024). DOI: 10.1038/s41467-024-44877-0The mechanism by which our brains record events in stereo—with one channel recordin

Updated on: July 05,2024

Hippocampus uses dual pathways for memory storage

byRIKENOverview and motivation. Credit:Nature Communications(2024). DOI: 10.1038/s41467-024-44877-0The mechanism by which our brains record events in stereo—with one channel recordin

Updated on:July 05,2024

Alzheimer's meds are mostly tested in whites. That worries Black patients, caregivers

by Sydney MurphyLarry Griner resigned from his job in California and moved back to his childhood home in Baltimore nearly five years ago so he could care for his mother, Norma.She had been diagnosed w

Updated on: April 08,2024

Alzheimer's meds are mostly tested in whites. That worries Black patients, caregivers

by Sydney MurphyLarry Griner resigned from his job in California and moved back to his childhood home in Baltimore nearly five years ago so he could care for his mother, Norma.She had been diagnosed w

Updated on:April 08,2024

Unlocking the mystery of tau for treatment of neurodegenerative diseases

by Nagoya UniversityUnder normal physiological conditions, FUS and SFPQ interact in the nucleus of nerve cells and regulate the alternative splicing of MAPT by excising exon 10. When this functio

Updated on: July 01,2024

Unlocking the mystery of tau for treatment of neurodegenerative diseases

by Nagoya UniversityUnder normal physiological conditions, FUS and SFPQ interact in the nucleus of nerve cells and regulate the alternative splicing of MAPT by excising exon 10. When this functio

Updated on:July 01,2024

Researchers identify neurons responsible for key activity transition in brain development

byKing's College LondonCredit:Neuron(2024). DOI: 10.1016/j.neuron.2024.03.014Scientists at the Center for Developmental Neurobiology and MRC Center for Neurodevelopmental Disorde

Updated on: April 28,2024

Researchers identify neurons responsible for key activity transition in brain development

byKing's College LondonCredit:Neuron(2024). DOI: 10.1016/j.neuron.2024.03.014Scientists at the Center for Developmental Neurobiology and MRC Center for Neurodevelopmental Disorde

Updated on:April 28,2024

Early diagnosis of Alzheimer's: Ultra-long protein fibrils give clues on dementia risk

by Swiss Federal Laboratories for Materials Science and TechnologyAtomic force microscopy: Peter Nirmalraj investigates Alzheimer's disease at the nanometer scale. Credit: EmpaThe early detec

Updated on: April 18,2024

Early diagnosis of Alzheimer's: Ultra-long protein fibrils give clues on dementia risk

by Swiss Federal Laboratories for Materials Science and TechnologyAtomic force microscopy: Peter Nirmalraj investigates Alzheimer's disease at the nanometer scale. Credit: EmpaThe early detec

Updated on:April 18,2024

Study finds cerebellar nuclei may be more important for associative learning than initially thought

by Champalimaud Centre for the UnknownAn artistic interpretation of the research. The bright algae represent mossy fibers—brain connections that interact with pufferfish, symbolizing the cerebellar nu

Updated on: January 10,2024

Study finds cerebellar nuclei may be more important for associative learning than initially thought

by Champalimaud Centre for the UnknownAn artistic interpretation of the research. The bright algae represent mossy fibers—brain connections that interact with pufferfish, symbolizing the cerebellar nu

Updated on:January 10,2024