Anticancer drugs could make immunotherapies more effective

byWeill Cornell Medical CollegePretreatment with EZH2 inhibitor (top right) leads to higher recruitment of CAR-T cells (red) into the lymph node tumor compared with control (top left). Pretreatm

Updated on: December 21,2024

Anticancer drugs could make immunotherapies more effective

byWeill Cornell Medical CollegePretreatment with EZH2 inhibitor (top right) leads to higher recruitment of CAR-T cells (red) into the lymph node tumor compared with control (top left). Pretreatm

Updated on:December 21,2024

How individual mutations of the tumor suppressor p53 affect pancreatic carcinomas

byUniversity of KonstanzMetabolic profile of p53 mutant variants in pancreatic cancer. Credit:Journal of Experimental & Clinical Cancer Research(2024). DOI: 10.1186/s13046-024-03

Updated on: December 21,2024

How individual mutations of the tumor suppressor p53 affect pancreatic carcinomas

byUniversity of KonstanzMetabolic profile of p53 mutant variants in pancreatic cancer. Credit:Journal of Experimental & Clinical Cancer Research(2024). DOI: 10.1186/s13046-024-03

Updated on:December 21,2024

First look at neuron–tumor connections in brain illuminates formation and spread of gliomas

by Stephanie Dutchen,Harvard Medical SchoolResearchers revealed which neurons in a mouse brain, shown in red, connect to a human glioma, shown in green. Image: Annie Hsieh. Credit:Proceedi

Updated on: December 20,2024

First look at neuron–tumor connections in brain illuminates formation and spread of gliomas

by Stephanie Dutchen,Harvard Medical SchoolResearchers revealed which neurons in a mouse brain, shown in red, connect to a human glioma, shown in green. Image: Annie Hsieh. Credit:Proceedi

Updated on:December 20,2024

PIVKA-II-based model IDs liver cancer risk in hep C-related cirrhosis

by Elana GotkineAmong patients with hepatitis C virus (HCV)-related cirrhosis with sustained virological response (SVR) to direct-acting antivirals (DAAs), a serum protein induced by vitamin K absence

Updated on: December 20,2024

PIVKA-II-based model IDs liver cancer risk in hep C-related cirrhosis

by Elana GotkineAmong patients with hepatitis C virus (HCV)-related cirrhosis with sustained virological response (SVR) to direct-acting antivirals (DAAs), a serum protein induced by vitamin K absence

Updated on:December 20,2024

Highly invasive tumor hijacks neurons to grow, but a common heart medication offers hope

byChinese Academy of SciencesMouse craniopharyngioma. Credit: IGDBChinese researchers have revealed new insights into the growth of craniopharyngioma and identified a potential therapeutic treat

Updated on: January 21,2025

Highly invasive tumor hijacks neurons to grow, but a common heart medication offers hope

byChinese Academy of SciencesMouse craniopharyngioma. Credit: IGDBChinese researchers have revealed new insights into the growth of craniopharyngioma and identified a potential therapeutic treat

Updated on:January 21,2025

Could a pill replace gene therapy for sickle cell disease? Research uncovers potential path to small-molecule drug

by Nancy Fliesler,Children's Hospital BostonNew work suggests ways to target the BCL11A protein with drugs, enabling patients with sickle cell disease to produce non-sickling fetal hemoglobi

Updated on: January 17,2025

Could a pill replace gene therapy for sickle cell disease? Research uncovers potential path to small-molecule drug

by Nancy Fliesler,Children's Hospital BostonNew work suggests ways to target the BCL11A protein with drugs, enabling patients with sickle cell disease to produce non-sickling fetal hemoglobi

Updated on:January 17,2025

Vitamin E succinate shown to control tumor growth and enhance immunotherapy effects

Updated on: March 25,2025

Vitamin E succinate shown to control tumor growth and enhance immunotherapy effects

Updated on:March 25,2025

Breast cancer treatment advances with light-activated 'smart bomb'

Updated on: March 25,2025

Breast cancer treatment advances with light-activated 'smart bomb'

Updated on:March 25,2025

Changes in blood cell production over the lifetime could impact leukemia outcomes

by Susanne Clara Bard,University of California - San DiegoCredit: Unsplash/CC0 Public DomainResearchers at University of California San Diego School of Medicine and their colleagues have develop

Updated on: December 21,2024

Changes in blood cell production over the lifetime could impact leukemia outcomes

by Susanne Clara Bard,University of California - San DiegoCredit: Unsplash/CC0 Public DomainResearchers at University of California San Diego School of Medicine and their colleagues have develop

Updated on:December 21,2024

Cancer risk declines in old age: New research helps explain why

by Ian Demsky,Memorial Sloan Kettering Cancer CenterAged AT2 cells exhibit reduced cell-intrinsic potential for regeneration and tumorigenesis. Credit:Nature(2024). DOI: 10.1038/s415

Updated on: December 21,2024

Cancer risk declines in old age: New research helps explain why

by Ian Demsky,Memorial Sloan Kettering Cancer CenterAged AT2 cells exhibit reduced cell-intrinsic potential for regeneration and tumorigenesis. Credit:Nature(2024). DOI: 10.1038/s415

Updated on:December 21,2024

New treatment target for neuroendocrine prostate cancer discovered

by Roswell Park Comprehensive Cancer CenterMitochondria are dysfunctional in neuroendocrine prostate tumors. Credit:Oncogene(2024). DOI: 10.1038/s41388-024-03261-4A team of researchers at

Updated on: January 22,2025

New treatment target for neuroendocrine prostate cancer discovered

by Roswell Park Comprehensive Cancer CenterMitochondria are dysfunctional in neuroendocrine prostate tumors. Credit:Oncogene(2024). DOI: 10.1038/s41388-024-03261-4A team of researchers at

Updated on:January 22,2025

Study reveals immune-modulatory mechanism of lurbinectedin in small-cell lung cancer

byThe Mount Sinai HospitalLurbinectedin augments the anti-tumor immune response of PD-L1 blockade in immunocompetent SCLC models. Credit:Cell Reports Medicine(2024). DOI: 10.1016/j.x

Updated on: January 21,2025

Study reveals immune-modulatory mechanism of lurbinectedin in small-cell lung cancer

byThe Mount Sinai HospitalLurbinectedin augments the anti-tumor immune response of PD-L1 blockade in immunocompetent SCLC models. Credit:Cell Reports Medicine(2024). DOI: 10.1016/j.x

Updated on:January 21,2025