Autophagy-tethering compounds may open new directions in targeted drug discovery

byScience China Press(A) Molecular glue ATTECs are targeting polyQ proteins in neurodegenerative disorders. (B) Bifunctional ATTECs targeting oncoprotein BRD4. (C) Bifunctional ATTECs targeting

Updated on: March 28,2024

Autophagy-tethering compounds may open new directions in targeted drug discovery

byScience China Press(A) Molecular glue ATTECs are targeting polyQ proteins in neurodegenerative disorders. (B) Bifunctional ATTECs targeting oncoprotein BRD4. (C) Bifunctional ATTECs targeting

Updated on:March 28,2024

New study examines dermal injections and their impact on skin aging

FEBRUARY 14, 2024by Tessa Roy,University of MichiganIncreased fibroblast synthetic activity as early as 1 week post-filler injection. Following injection of vehicle (saline) and filler (cross-li

Updated on: March 29,2024

New study examines dermal injections and their impact on skin aging

FEBRUARY 14, 2024by Tessa Roy,University of MichiganIncreased fibroblast synthetic activity as early as 1 week post-filler injection. Following injection of vehicle (saline) and filler (cross-li

Updated on:March 29,2024

A molecular route to decoding synaptic specificity and nerve cell communication

by Tokyo Institute of TechnologyThis study provides insights into the molecular mechanisms underlying the neuronal synaptic interaction. Credit: Tokyo TechNeurons or nerve cells are the fundament

Updated on: April 06,2024

A molecular route to decoding synaptic specificity and nerve cell communication

by Tokyo Institute of TechnologyThis study provides insights into the molecular mechanisms underlying the neuronal synaptic interaction. Credit: Tokyo TechNeurons or nerve cells are the fundament

Updated on:April 06,2024

Knowing how clinicians make real-world decisions about drug-drug interactions can improve patient safety

by Regenstrief InstituteDescriptive model of clinicians’ DDI decision-making process. This figure shows the coding tree developed during the inductive qualitative analysis, with primary themes sh

Updated on: January 26,2024

Knowing how clinicians make real-world decisions about drug-drug interactions can improve patient safety

by Regenstrief InstituteDescriptive model of clinicians’ DDI decision-making process. This figure shows the coding tree developed during the inductive qualitative analysis, with primary themes sh

Updated on:January 26,2024

An aspirin a day? Poll of older adults suggests some who take it may be following outdated advice

by University of MichiganCredit: Pixabay/CC0 Public DomainOne in four older adults take aspirin at least three times a week, mostly in hopes of preventing heart attacks and strokes, a new poll sh

Updated on: March 20,2024

An aspirin a day? Poll of older adults suggests some who take it may be following outdated advice

by University of MichiganCredit: Pixabay/CC0 Public DomainOne in four older adults take aspirin at least three times a week, mostly in hopes of preventing heart attacks and strokes, a new poll sh

Updated on:March 20,2024

Pharmacy researchers examine trends in rising cost of medicine

by Laurie Fickman,University of HoustonCredit: Unsplash/CC0 Public DomainNewly published research from the University of Houston College of Pharmacy reveals an alarming trend in diabetic medicat

Updated on: April 28,2024

Pharmacy researchers examine trends in rising cost of medicine

by Laurie Fickman,University of HoustonCredit: Unsplash/CC0 Public DomainNewly published research from the University of Houston College of Pharmacy reveals an alarming trend in diabetic medicat

Updated on:April 28,2024

Ozempic mania's billions in bills are coming for US taxpayers

by Simone Foxman, Laura Nahmias, Bloomberg NewsCredit: Markus Winkler from PexelsState and local governments across the US are grappling with a growing problem: Expensive drugs to treat diabetes and o

Updated on: January 26,2024

Ozempic mania's billions in bills are coming for US taxpayers

by Simone Foxman, Laura Nahmias, Bloomberg NewsCredit: Markus Winkler from PexelsState and local governments across the US are grappling with a growing problem: Expensive drugs to treat diabetes and o

Updated on:January 26,2024

Comparing human and mouse Purkinje cells to better understand human brain complexity

by Bob Yirka , Medical XpressHuman and mouse PC morphological properties. a Morphological reconstructions of a mouse and a human PC obtained from fluorescent confocal images of postmortem fixated brai

Updated on: January 09,2024

Comparing human and mouse Purkinje cells to better understand human brain complexity

by Bob Yirka , Medical XpressHuman and mouse PC morphological properties. a Morphological reconstructions of a mouse and a human PC obtained from fluorescent confocal images of postmortem fixated brai

Updated on:January 09,2024

Lifespan increases in mice when specific brain cells are activated, study finds

by Julia Evangelou Strait,Washington University School of MedicineWith age, the researchers found that the protein Ppp1r17 tends to leave the nucleus of the neurons, and when that happens, the n

Updated on: January 09,2024

Lifespan increases in mice when specific brain cells are activated, study finds

by Julia Evangelou Strait,Washington University School of MedicineWith age, the researchers found that the protein Ppp1r17 tends to leave the nucleus of the neurons, and when that happens, the n

Updated on:January 09,2024

US company withdraws ALS drug after it fails in trial

An MRI with increased signal in the posterior part of the internal capsule which can be tracked to the motor cortex consistent with the diagnosis of ALS. Credit: Frank Gaillard/WikipediaAmylyx Pharmac

Updated on: April 06,2024

US company withdraws ALS drug after it fails in trial

An MRI with increased signal in the posterior part of the internal capsule which can be tracked to the motor cortex consistent with the diagnosis of ALS. Credit: Frank Gaillard/WikipediaAmylyx Pharmac

Updated on:April 06,2024

West Virginia city once battered by opioid overdoses confronts 'fourth wave'

by Taylor Sisk, KFF Health NewsCredit: CC0 Public DomainFrom 2006 through 2014, more than 81 million painkiller pills were shipped to this city and surrounding rural Cabell County.The arrival of presc

Updated on: March 28,2024

West Virginia city once battered by opioid overdoses confronts 'fourth wave'

by Taylor Sisk, KFF Health NewsCredit: CC0 Public DomainFrom 2006 through 2014, more than 81 million painkiller pills were shipped to this city and surrounding rural Cabell County.The arrival of presc

Updated on:March 28,2024

Cutting through the fog of long COVID

Updated on: November 09,2024

Cutting through the fog of long COVID

Updated on:November 09,2024