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Breakthroughs
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Biological engineers discover why a promising drug failed in clinical trials

Biological engineers discover why a promising drug failed in clinical trials

by Anne Trafton,Massachusetts Institute of TechnologyRheumatoid arthritis, which afflicts more than 1 million Americans, is an autoimmune disorder that produces swollen and painful joints, prima

Biological engineers discover why a promising drug failed in clinical trials

by Anne Trafton,Massachusetts Institute of TechnologyRheumatoid arthritis, which afflicts more than 1 million Americans, is an autoimmune disorder that produces swollen and painful joints, prima
New wearable patch measures trace perspiration during activity and rest

New wearable patch measures trace perspiration during activity and rest

byUniversity of TsukubaConceptual illustration portrays fully assembled patch securely affixed to skin's surface. Credit:Advanced Science(2024). DOI: 10.1002/advs.202401947Resear

New wearable patch measures trace perspiration during activity and rest

byUniversity of TsukubaConceptual illustration portrays fully assembled patch securely affixed to skin's surface. Credit:Advanced Science(2024). DOI: 10.1002/advs.202401947Resear
New web portal empowers drug discovery, systems-level analysis of critical kinase-substrate interactions

New web portal empowers drug discovery, systems-level analysis of critical kinase-substrate interactions

byThe Mount Sinai HospitalKiNet functionalities. Credit:npj Systems Biology and Applications(2024). DOI: 10.1038/s41540-024-00442-5Researchers from the Icahn School of Medicine at Mo

New web portal empowers drug discovery, systems-level analysis of critical kinase-substrate interactions

byThe Mount Sinai HospitalKiNet functionalities. Credit:npj Systems Biology and Applications(2024). DOI: 10.1038/s41540-024-00442-5Researchers from the Icahn School of Medicine at Mo
The genomic architecture of inherited DNA variants

The genomic architecture of inherited DNA variants

by Graciela Gutierrez,Baylor College of MedicineCredit: Pixabay/CC0 Public DomainYou have your mother's eyes and your father's smile, but genetics is much more than just what's on th

The genomic architecture of inherited DNA variants

by Graciela Gutierrez,Baylor College of MedicineCredit: Pixabay/CC0 Public DomainYou have your mother's eyes and your father's smile, but genetics is much more than just what's on th
Spot-on laser treatment for skin blemishes becoming clearer with new index

Spot-on laser treatment for skin blemishes becoming clearer with new index

by Osaka Metropolitan UniversityLeft: Unirradiated melanosomes show a smooth surface. Right: Irradiation by picosecond lasers with a pulse width of 450 ps at a wavelength of 1,064 nm and a fluenc

Spot-on laser treatment for skin blemishes becoming clearer with new index

by Osaka Metropolitan UniversityLeft: Unirradiated melanosomes show a smooth surface. Right: Irradiation by picosecond lasers with a pulse width of 450 ps at a wavelength of 1,064 nm and a fluenc
SGLT-2 inhibitors show mixed results after heart attack

SGLT-2 inhibitors show mixed results after heart attack

byAmerican College of CardiologyCredit: Unsplash/CC0 Public DomainWhile the composite of death and heart failure hospitalizations was not significantly reduced, empagliflozin may help reduce hea

SGLT-2 inhibitors show mixed results after heart attack

byAmerican College of CardiologyCredit: Unsplash/CC0 Public DomainWhile the composite of death and heart failure hospitalizations was not significantly reduced, empagliflozin may help reduce hea
The year in opioid settlements: 5 things you need to know

The year in opioid settlements: 5 things you need to know

DECEMBER 30, 2023 Editors' notesby Aneri Pattani, KFF Health NewsCredit: Pixabay/CC0 Public DomainThis year, about $1.5 billion has landed in state and local government coffers from court settleme

The year in opioid settlements: 5 things you need to know

DECEMBER 30, 2023 Editors' notesby Aneri Pattani, KFF Health NewsCredit: Pixabay/CC0 Public DomainThis year, about $1.5 billion has landed in state and local government coffers from court settleme
Study of palliative care demonstrates scalable strategy to increase support for seriously ill patients in hospital

Study of palliative care demonstrates scalable strategy to increase support for seriously ill patients in hospital

JANUARY 16, 2024byPerelman School of Medicine at the University of PennsylvaniaCredit: Unsplash/CC0 Public DomainOrdering a palliative care consultation by "default"—via an automatic o

Study of palliative care demonstrates scalable strategy to increase support for seriously ill patients in hospital

JANUARY 16, 2024byPerelman School of Medicine at the University of PennsylvaniaCredit: Unsplash/CC0 Public DomainOrdering a palliative care consultation by "default"—via an automatic o
New genome editing tools unlock possibilities for precision medicine

New genome editing tools unlock possibilities for precision medicine

by Stephan Wiegand,Dresden University of TechnologyDesign of ZFDs for the loxF8 genomic locus. a, Genomic sequences flanking loxF8. Binding sites of the designed ZFDs upstream (orange, ZFL1–2) a

New genome editing tools unlock possibilities for precision medicine

by Stephan Wiegand,Dresden University of TechnologyDesign of ZFDs for the loxF8 genomic locus. a, Genomic sequences flanking loxF8. Binding sites of the designed ZFDs upstream (orange, ZFL1–2) a
A computational model to simulate the biomechanical growth of breast tumors

A computational model to simulate the biomechanical growth of breast tumors

byCarlos III University of MadridTumor cells invading surrounding tissue under different mechanical conditions. The blue line indicates the boundary of the solid tumor and the yellow line indica

A computational model to simulate the biomechanical growth of breast tumors

byCarlos III University of MadridTumor cells invading surrounding tissue under different mechanical conditions. The blue line indicates the boundary of the solid tumor and the yellow line indica
Pharmacologic restraint used in 3 percent of pediatric mental health admissions

Pharmacologic restraint used in 3 percent of pediatric mental health admissions

by Elana GotkineThe use of pharmacologic restraints occurs in 3 percent of hospitalizations for children admitted with a primary mental health diagnosis, according to a study published online Dec. 11

Pharmacologic restraint used in 3 percent of pediatric mental health admissions

by Elana GotkineThe use of pharmacologic restraints occurs in 3 percent of hospitalizations for children admitted with a primary mental health diagnosis, according to a study published online Dec. 11