New genome editing tools unlock possibilities for precision medicine

by Stephan Wiegand,Dresden University of TechnologyDesign of ZFDs for the loxF8 genomic locus. a, Genomic sequences flanking loxF8. Binding sites of the designed ZFDs upstream (orange, ZFL1–2) a

Updated on: April 23,2024

New genome editing tools unlock possibilities for precision medicine

by Stephan Wiegand,Dresden University of TechnologyDesign of ZFDs for the loxF8 genomic locus. a, Genomic sequences flanking loxF8. Binding sites of the designed ZFDs upstream (orange, ZFL1–2) a

Updated on:April 23,2024

AI-supported image analysis: How metrics determine quality

FEBRUARY 12, 2024byGerman Cancer Research CenterP1: Pitfalls related to the inadequate choice of the problem category. The effect of using segmentation metrics for object-detection problems. The

Updated on: March 25,2024

AI-supported image analysis: How metrics determine quality

FEBRUARY 12, 2024byGerman Cancer Research CenterP1: Pitfalls related to the inadequate choice of the problem category. The effect of using segmentation metrics for object-detection problems. The

Updated on:March 25,2024

First clinical trial of vosoritide for children with hypochondroplasia shows increased growth

byChildren's National HospitalStanding height SDS. Credit:eClinicalMedicine(2024). DOI: 10.1016/j.eclinm.2024.102591Vosoritide's first global Phase II study showed an average

Updated on: April 28,2024

First clinical trial of vosoritide for children with hypochondroplasia shows increased growth

byChildren's National HospitalStanding height SDS. Credit:eClinicalMedicine(2024). DOI: 10.1016/j.eclinm.2024.102591Vosoritide's first global Phase II study showed an average

Updated on:April 28,2024

Lactate-driven regulatory pathway in dendritic cells serves as a novel therapeutic target for treating autoimmunity

Updated on: August 14,2024

Lactate-driven regulatory pathway in dendritic cells serves as a novel therapeutic target for treating autoimmunity

Updated on:August 14,2024

How the body switches out of 'fight' mode: Study shows hormones reprogram metabolism of immune cells

byCharité - Universitätsmedizin BerlinA macrophage activated by an inflammatory stimulus after being treated with cortisone. Cortisone affects not only the genes in the nucleus (blue), but also

Updated on: April 27,2024

How the body switches out of 'fight' mode: Study shows hormones reprogram metabolism of immune cells

byCharité - Universitätsmedizin BerlinA macrophage activated by an inflammatory stimulus after being treated with cortisone. Cortisone affects not only the genes in the nucleus (blue), but also

Updated on:April 27,2024

Oleic acid: A potential therapy for people with a rare genetic condition

byUniversity of California, Los AngelesCredit: Pixabay/CC0 Public DomainA mutation in a protein regulating natural killer (NK) cells' function is at the root of immune deficiency in some peo

Updated on: April 27,2024

Oleic acid: A potential therapy for people with a rare genetic condition

byUniversity of California, Los AngelesCredit: Pixabay/CC0 Public DomainA mutation in a protein regulating natural killer (NK) cells' function is at the root of immune deficiency in some peo

Updated on:April 27,2024

Longitudinal characterization of behavioral, morphological and transcriptomic changes in a tauopathy mouse model

by Impact Journals LLCGene expression profiling revealed various patterns of changes in PFC and hippocampus of P301S mice at different ages. Credit:Aging(2023). DOI: 10.18632/aging.205057A

Updated on: January 10,2024

Longitudinal characterization of behavioral, morphological and transcriptomic changes in a tauopathy mouse model

by Impact Journals LLCGene expression profiling revealed various patterns of changes in PFC and hippocampus of P301S mice at different ages. Credit:Aging(2023). DOI: 10.18632/aging.205057A

Updated on:January 10,2024

Optical biosensor rapidly detects monkeypox virus

by Susanne Clara Bard,University of California - San DiegoPrototype of PD-IRIS (a). A conical light integrating device (LID) is used to mix two wavelengths. Uniformly mixed output light at two d

Updated on: December 03,2024

Optical biosensor rapidly detects monkeypox virus

by Susanne Clara Bard,University of California - San DiegoPrototype of PD-IRIS (a). A conical light integrating device (LID) is used to mix two wavelengths. Uniformly mixed output light at two d

Updated on:December 03,2024

SGLT-2 inhibitors show mixed results after heart attack

byAmerican College of CardiologyCredit: Unsplash/CC0 Public DomainWhile the composite of death and heart failure hospitalizations was not significantly reduced, empagliflozin may help reduce hea

Updated on: April 28,2024

SGLT-2 inhibitors show mixed results after heart attack

byAmerican College of CardiologyCredit: Unsplash/CC0 Public DomainWhile the composite of death and heart failure hospitalizations was not significantly reduced, empagliflozin may help reduce hea

Updated on:April 28,2024

Research finds peer support vital for those taking medication for severe mental illness

byAston UniversityCredit: Pixabay/CC0 Public DomainResearchers at Aston Pharmacy School have found that people with severe mental illness could benefit from peer support to help them manage thei

Updated on: January 26,2024

Research finds peer support vital for those taking medication for severe mental illness

byAston UniversityCredit: Pixabay/CC0 Public DomainResearchers at Aston Pharmacy School have found that people with severe mental illness could benefit from peer support to help them manage thei

Updated on:January 26,2024

Researchers pinpoint issue that could be hampering common chemotherapy drug

by Anika Hazra,University of TorontoGenome-wide CRISPR–Cas9 screens reveal modulators of gemcitabine sensitivity. Credit:Nature Cancer(2024). DOI: 10.1038/s43018-024-00742-zResearche

Updated on: March 28,2024

Researchers pinpoint issue that could be hampering common chemotherapy drug

by Anika Hazra,University of TorontoGenome-wide CRISPR–Cas9 screens reveal modulators of gemcitabine sensitivity. Credit:Nature Cancer(2024). DOI: 10.1038/s43018-024-00742-zResearche

Updated on:March 28,2024

A computational model to simulate the biomechanical growth of breast tumors

byCarlos III University of MadridTumor cells invading surrounding tissue under different mechanical conditions. The blue line indicates the boundary of the solid tumor and the yellow line indica

Updated on: March 28,2024

A computational model to simulate the biomechanical growth of breast tumors

byCarlos III University of MadridTumor cells invading surrounding tissue under different mechanical conditions. The blue line indicates the boundary of the solid tumor and the yellow line indica

Updated on:March 28,2024