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New web portal empowers drug discovery, systems-level analysis of critical kinase-substrate interactions

New web portal empowers drug discovery, systems-level analysis of critical kinase-substrate interactions

byThe Mount Sinai HospitalKiNet functionalities. Credit:npj Systems Biology and Applications(2024). DOI: 10.1038/s41540-024-00442-5Researchers from the Icahn School of Medicine at Mo

New web portal empowers drug discovery, systems-level analysis of critical kinase-substrate interactions

byThe Mount Sinai HospitalKiNet functionalities. Credit:npj Systems Biology and Applications(2024). DOI: 10.1038/s41540-024-00442-5Researchers from the Icahn School of Medicine at Mo
Researchers define new subtypes of common brain disorder

Researchers define new subtypes of common brain disorder

by Mark Reynolds,Washington University School of MedicineAn MRI scan shows a Chiari type-1 malformation, in which the cerebellum extends beyond the gap in the skull where it connects to the spin

Researchers define new subtypes of common brain disorder

by Mark Reynolds,Washington University School of MedicineAn MRI scan shows a Chiari type-1 malformation, in which the cerebellum extends beyond the gap in the skull where it connects to the spin
New study finds systematic biases at play in clinical trials

New study finds systematic biases at play in clinical trials

byMichigan State UniversityCredit: Pixabay/CC0 Public DomainRandomized controlled trials, or RCTs, are believed to be the best way to study the safety and efficacy of new treatments in clinical

New study finds systematic biases at play in clinical trials

byMichigan State UniversityCredit: Pixabay/CC0 Public DomainRandomized controlled trials, or RCTs, are believed to be the best way to study the safety and efficacy of new treatments in clinical
Study identifies epigenetic 'switches' that regulate the developmental trajectories of single cells

Study identifies epigenetic 'switches' that regulate the developmental trajectories of single cells

by Ingrid Fadelli , Medical XpressAnalysis of the developmental cell atlas. a, Workflow to obtain single-cell RNA (scRNA) expression and CUT&Tag data for three histone modifications (H3K27me3, H3K

Study identifies epigenetic 'switches' that regulate the developmental trajectories of single cells

by Ingrid Fadelli , Medical XpressAnalysis of the developmental cell atlas. a, Workflow to obtain single-cell RNA (scRNA) expression and CUT&Tag data for three histone modifications (H3K27me3, H3K
All stem cell therapies are not created equally: Some don't have many stem cells at all, researchers find

All stem cell therapies are not created equally: Some don't have many stem cells at all, researchers find

byUniversity of California - San DiegoCredit: Pixabay/CC0 Public DomainResearchers from University of California San Diego have found that two of the most frequently administered stem cell thera

All stem cell therapies are not created equally: Some don't have many stem cells at all, researchers find

byUniversity of California - San DiegoCredit: Pixabay/CC0 Public DomainResearchers from University of California San Diego have found that two of the most frequently administered stem cell thera
Predicting neurodevelopmental disease in children from parents' traits

Predicting neurodevelopmental disease in children from parents' traits

by Sam Sholtis,Pennsylvania State UniversityNeurodevelopmental and psychiatric disorders, and the genes that can lead to them, vary in a population (left, brighter red colors represent more seve

Predicting neurodevelopmental disease in children from parents' traits

by Sam Sholtis,Pennsylvania State UniversityNeurodevelopmental and psychiatric disorders, and the genes that can lead to them, vary in a population (left, brighter red colors represent more seve
Genetic testing pinpoints cardiovascular risk in patients with aortic disorders

Genetic testing pinpoints cardiovascular risk in patients with aortic disorders

by Vincent Jacobbi,Mayo ClinicCredit: Pixabay/CC0 Public DomainA new Mayo Clinic systematicreview, published in theJournal of Vascular Surgeryhas shed light on genetically inhe

Genetic testing pinpoints cardiovascular risk in patients with aortic disorders

by Vincent Jacobbi,Mayo ClinicCredit: Pixabay/CC0 Public DomainA new Mayo Clinic systematicreview, published in theJournal of Vascular Surgeryhas shed light on genetically inhe
Review paper unveils the potential of suppressor tRNA in gene therapy

Review paper unveils the potential of suppressor tRNA in gene therapy

byScience China PressCredit: Science China PressA review article provides a comprehensive overview of the biological mechanisms of suppressor tRNA, traces the development history of related rese

Review paper unveils the potential of suppressor tRNA in gene therapy

byScience China PressCredit: Science China PressA review article provides a comprehensive overview of the biological mechanisms of suppressor tRNA, traces the development history of related rese
How aging affects stem cells: A fly's tale

How aging affects stem cells: A fly's tale

byRIKENExcessive cell proliferation (left) and stem cell exhaustion (right) during aging. Credit: RIKENScientists from the RIKEN Center for Biosystems Dynamics Research (BDR) have identified key

How aging affects stem cells: A fly's tale

byRIKENExcessive cell proliferation (left) and stem cell exhaustion (right) during aging. Credit: RIKENScientists from the RIKEN Center for Biosystems Dynamics Research (BDR) have identified key
Researchers find mitochondrial DNA damage triggers spread of Parkinson's disease-like pathology

Researchers find mitochondrial DNA damage triggers spread of Parkinson's disease-like pathology

byUniversity of CopenhagenComplex I respiratory chain subunits are altered in PD patients and PD models(Ifnb-/-/Ifnar1-/-) due to mtDNA damages.AEnrichment plot of KEGG-OXPHOS

Researchers find mitochondrial DNA damage triggers spread of Parkinson's disease-like pathology

byUniversity of CopenhagenComplex I respiratory chain subunits are altered in PD patients and PD models(Ifnb-/-/Ifnar1-/-) due to mtDNA damages.AEnrichment plot of KEGG-OXPHOS